期刊论文

中文

中华中医药学刊

1673-7717

2011

29

6

1336-1337

10.13193/j.archtcm.2011.06.146.xiemzh.022

湖南省自然科学基金资助项目（07JJ6042,07JJ4006） 湖南中医药大学中医诊断国家重点学科联合资助项目

本校为第一机构

目的:探讨杏仁核黑皮质素受体(MCR)与"消谷善饥"的相关性.方法:SD雄鼠随机分两组,行杏仁中央核(CeA)插管并分别注射MCR4拮抗剂HS014(1nmol,lμL)和生理盐水(1μL),观察药物对动物摄食及体重的影响.结果:与生理盐水对照组比较,CeA微量注射HS014,12、24h内大鼠的摄食分别为(82.61士15.72)kcal、(146.51土17.53)kcal,显著高于时照组(61.23土14.82)kcal、(119.87土18.86)kcal(P

Objective： To explore the relationship between amygdala melanocortin receptor antagonist HS014 and TCM term Swift Digestion with Rapid Hungering（SDRH）.Methods： Male Sprague-Dawley（SD） rats were randomly divided into two groups,then receiving cannula implant in central nucleus of the amygdala（CeA）,and were treated with MCR antagonist HS014（1nmol,1μL） and saline（1μL） respectively.The food intake,as well as body weight increase was measured.Results： Compared to the saline treatment,injection of HS014 in CeA could increase the food i...