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Comparison of the effects of Shenfu injection and Shenmai injection on doxorubicin-induced chronic heart failure in rats

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成果类型:
期刊论文
作者:
Zhou, Yao;Zhong, Senjie;Hu, Siyuan;Dong, Wenbo;Yao, Tao;...
通讯作者:
Hu, Zhixi
作者机构:
[Zhou, Yao; Zhong, Senjie; Dong, Wenbo; Hu, Siyuan; Yao, Tao] Hunan Univ Chinese Med, Postgrad Sch, Changsha 410208, Hunan, Peoples R China.
[Zhou, Yao] Hunan Tradit Chinese Med Coll, Dept Med, Zhuzhou 412012, Peoples R China.
[Hu, Zhixi; Li, Lin; Liang, Hao] Hunan Univ Chinese Med, Hunan Prov Key Lab Diagnost Chinese Med, 300C Xueshi Rd, Changsha 410208, Hunan, Peoples R China.
通讯机构:
[Hu, Zhixi] H
Hunan Univ Chinese Med, Hunan Prov Key Lab Diagnost Chinese Med, 300C Xueshi Rd, Changsha 410208, Hunan, Peoples R China.
语种:
英文
关键词:
Chronic heart failure;doxorubicin;traditional Chinese medicine;Nrf2
期刊:
International Journal of Clinical and Experimental Medicine
ISSN:
1940-5901
年:
2018
卷:
11
期:
12
页码:
13169-13179
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81373550, 81774208, 81503627]
机构署名:
本校为第一且通讯机构
院系归属:
中医学院
研究生院
摘要:
Shenfu injection (SFI) and Shenmai injection (SMI) are classical Traditional Chinese Medicine (TCM) for chronic heart failure (CHF). SFI is used for Yang Deficiency syndrome, while SMI is used for Yin Deficiency. The present study aimed to investigate the effects of SFI and SMI on doxorubicin (DOX) induced chronic heart failure (CHF) in a rat model. A total of 33 CHF rats were successfully established and received 15 days of SFI and SMI treatment, followed by dividing into the DOX group, SMI group, and SFI group. Another 11 rats were chosen as the control group. Echocardiograms and carotid art...

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