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Development of a nanodrug-delivery system camouflaged by erythrocyte membranes for the chemo/phototherapy of cancer

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成果类型:
期刊论文
作者:
Daniyal, Muhammad;Jian, YuQing;Xiao, Feng;Sheng, Wenbing;Fan, Jialong;...
通讯作者:
Wang, W;Liu, B
作者机构:
[Sheng, Wenbing; Peng, Caiyun; Wang, Wei; Jian, YuQing; Daniyal, Muhammad; Qin Yuhui] Hunan Univ Chinese Med, Sch Pharm, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Hunan, Peoples R China.
[Liu, B; Fan, Jialong; Wang, Zhou; Xiao, Feng; Liu, Bin; Xiao, Chang] Hunan Univ, Coll Biol, Changsha 410082, Peoples R China.
通讯机构:
[Liu, B ; Wang, W ] H
Hunan Univ Chinese Med, Sch Pharm, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Hunan, Peoples R China.
Hunan Univ, Coll Biol, Changsha 410082, Peoples R China.
语种:
英文
关键词:
antineoplastic agent;caspase;ferric ferrocyanide;folic acid;nanoparticle;Pronephrium penangianum;protein Bax;protein bcl 2;unclassified drug;nanoparticle;animal experiment;animal model;animal tissue;Article;cancer chemotherapy;controlled study;drug delivery system;drug design;drug half life;drug mechanism;enzyme repression;erythrocyte membrane;female;human;immune evasion;in vivo study;mouse;nonhuman;photochemotherapy;priority journal;protein cleavage;uterine cervix cancer;animal;neoplasm;nude mouse;phototherapy;thermotherapy;Animals;Drug Delivery Systems;Erythrocyte Membrane;Folic Acid;Hyperthermia, Induced;Mice;Mice, Nude;Nanoparticles;Neoplasms;Phototherapy
期刊:
NANOMEDICINE
ISSN:
1743-5889
年:
2020
卷:
15
期:
7
页码:
691-709
基金类别:
This work was partially supported by the Natural Science Foundation of China (81673579 and 81874369), Ministry of Science and Technology (2018YFC1707902 and 2018FY100703), Hunan Department of Science and Technology (2018Wk2081 and 2018SK2110). National Natural Science Foundation of China (No. 81803708). National Natural Science Foundation of Hunan Province (2018JJ3386). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. This work was partially supported by the Natural Science Foundation of China (81673579 and 81874369), Ministry of Science and Technology (2018YFC1707902 and 2018FY100703), Hunan Department of Science and Technology (2018Wk2081 and 2018SK2110). National Natural Science Foundation of China (No. 81803708). National Natural Science Foundation of Hunan Province (2018JJ3386). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
机构署名:
本校为第一且通讯机构
院系归属:
药学院
摘要:
Aim: Development of a new drug-delivery system using a compound derived from Pronephrium penangianum (J5) for the treatment of cervical cancer. Materials & methods: The delivery system was developed using Prussian blue nanoparticles, camouflaged by red blood cell membrane and with folic acid surface modifications. Results: Our results showed the successful development of a nanodrug-delivery system, which increases the half-life and immune evasion ability of the drug. The mechanism of this system was through suppressing B-cell lymphoma 2 and inc...

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