Honokiol-Chlorambucil Co-Prodrugs Selectively Enhance the Killing Effect through STAT3 Binding on Lymphocytic Leukemia Cells in Vitro and in Vivo

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成果类型：

期刊论文

作者：

Xia, Li;Kang, Dali;Wan, Dan;Chu, Chu;Chen, Meizi;...

通讯作者：

Liu, Teng;Peng, Yongbo

作者机构：

[Kang, Dali; Xia, Li] Guangdong Food & Drug Vocat Coll, Sch Tradit Chinese Med, Guangzhou 510520, Peoples R China.

[Kang, Dali; Liu, Teng] Cent South Univ, Xiangya Hosp, Dept Pediat, Changsha 410008, Peoples R China.

[Zhang, Shuihan; Peng, Yongbo; Li, Xiong; Yan, Jianye; Wan, Dan] Hunan Acad Tradit Chinese Med, Inst Chinese Med, Changsha 410208, Peoples R China.

[Zhang, Shuihan; Peng, Yongbo; Li, Xiong; Yan, Jianye; Wan, Dan] Hunan Univ Chinese Med, Innovat Ctr Sci & Technol, Changsha 410208, Peoples R China.

[Peng, Yongbo; Wan, Dan] Hunan Univ, State Key Lab Chemo Biosensing & Chemomei, Coll Life Sci, Mol Sci & Biomed Lab, Changsha 410082, Hunan, Peoples R China.

通讯机构：

[Liu, Teng] C

[Peng, Yongbo] H

Cent South Univ, Xiangya Hosp, Dept Pediat, Changsha 410008, Peoples R China.

Hunan Acad Tradit Chinese Med, Inst Chinese Med, Changsha 410208, Peoples R China.

Hunan Univ Chinese Med, Innovat Ctr Sci & Technol, Changsha 410208, Peoples R China.

语种：

英文

期刊：

ACS OMEGA

ISSN：

2470-1343

年：

2020

卷：

期：

页码：

19844-19852

DOI：

10.1021/acsomega.0c02832

基金类别：

This research was supported by the National Natural Science Foundation of China (81803693), Key Research and Development Project of Hunan Province (2019NK2101), and Natural Science Foundation of Hunan Province (2020JJ5913), the Training Program for Outstanding Young Teachers in Higher Education Institutions of Guangdong Province in 2015 (no. YQ2015196) and Natural Science Fund Project of Guangdong Province (no. 2018A030313225). And we thank for Professor Jun Xu’s molecular docking help (School of pharmacy, Jinan University in Guangzhou).

机构署名：

本校为通讯机构

院系归属：

中医学院

摘要：

The broad-spectrum DNA alkylating therapeutic, chlorambucil (CBL), has limited safety and shows lower therapy effect because of a short half-life while used in the clinic. Therefore, it is very necessary to develop a more efficient and safer type of CBL derivate against tumors with selective targeting of cancer cells. In addition, the natural product of honokiol (HN), the novel potent chemo-preventive or therapeutic entity/carrier, can target the mitochondria of cancer cells through STAT3 to prevent cancer from spreading and metastasizing. In t...

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Honokiol-Chlorambucil Co-Prodrugs Selectively Enhance the Killing Effect through STAT3 Binding on Lymphocytic Leukemia Cells in Vitro and in Vivo

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