期刊论文

中文

中国药房

1001-0408

2010

21

29

2725-2727

本校为第一机构

目的:研究秦皮甲素的平衡溶解度及表观油/水分配系数, 为其吸收机制研究奠定基础.方法:将秦皮甲素分别溶解于 pH l.2-8.0的不同介质中, 以饱和法测定其平衡溶解度, 摇瓶法测定其表观油/水分配系数.结果:秦皮甲素的平衡溶解度在pH 1.2-6.8之间略有波动, pH 7.4时开始急剧增大, 并在pH 8.0达到峰值(10.58 g·L~(-1));其表观油/水分配系数在pH l.2-6.0之间变化缓慢, pH 6.0时开始明显下降, 并在pH 8.0达到最低值(0.03).结论:秦皮甲素的平衡溶解度及表观油/水分配系数与介质的pH值有关, 其口服后无降低血尿酸作用的原因可能与胃肠道吸收较差有关.

OBJECTIVE： To study the equilibrium solubility of aesculin and its apparent oil/water partition coefficient, and to provide basis for absorption mechanism study. METHODS： Equilibrium solubility of aesculin at the pH of 1.2-8.0 was determined by saturation method. The apparent oil/water partition coefficients of aesculin were determined by shaking flask method. RESULTS： The equilibrium solubility of aesculin at the pH of 1.2-6.8 was fluctuated slightly; it increased rapidly at the pH of 7.4; the maximum equilibrium solubility of aesculin was ...