OBJECTIVE: To explore the optimal concentration of honey to enhance the effect of acyclovir (ACV) on the rabbits with herpes simplex virus keratitis (HSK), and to provide reference for drug combination. METHODS: Rabbit cornea were vaccinated against type I herpes simplex strain by epithelium scratch method to establish HSK model. Model rabbits were randomly divided into 7 groups with 4 rabbits (8 eyes) in each group: i.e. groups I -IV (gel of honey mixed with 3% ACV, containing 0, 3%, 5%, 7% honey) ; group V (model established only)...