期刊论文

中文

中国药房

1001-0408

2020

31

1

24-29

10.6039/j.issn.1001-0408.2020.01.05

国家自然科学基金资助项目(No.81860844) 贵州省科技计划项目(No.黔科合基础[2016]1016、No.黔科合基础[2019]1038号) 贵州省教育厅青年科技人才成长项目(No.黔教合KY字[2016]185) 贵州省中医药管理局中医药、民族医药科学技术研究课题(No.QZYY-2016-001)。

本校为其他机构

目的:研究芎麻汤提取物对肝阳上亢兼瘀血型偏头痛模型大鼠脑组织中5-羟色胺(5-HT)、降钙素基因相关肽(CGRP)的影响.方法:将50只雄性自发性高血压(SHR)大鼠按血压随机分为模型对照组、正天丸阳性对照组(1.6 g/kg)和芎麻汤提取物低、中、高剂量组(4.5、9.0、18.0 g/kg,以生药量计),每组10只;并另取10只正常大鼠作为正常对照组.给药组大鼠分别灌胃相应药物,每天1次,连续28 d;正常对照组和模型对照组大鼠灌胃等体积生理盐水.末次给药后,除正常对照组外,其余各组大鼠均采用电刺激三叉神经节(10 min)法复制肝阳上亢兼瘀血型偏头痛大鼠模型,并于造模后再维持给药1次.30 min后,观察大鼠一般行为学及舌质...

OBJECTIVE:To study the effects of the extract of Xiongmatang on 5-HT and CGRP in brain tissue of rats with liver-yang hyperactivity and blood stagnation migraine. METHODS:Fifty male spontaneously hypertension(SHR) rats were randomly divided into model control group,Zhengtian pill positive control group(1.6 g/kg),the extract of Xiongmatang lowdose,medium-dose and high-dose groups(4.5,9.0,18.0 g/kg,by crude drug),with 10 rats in each group. Another 10 normal rats were taken as normal control group. Administration group was given relevant medicine intragastrically,once a day,for consecutive 28 d....