Benzophenone glycosides from the flower buds of Aquilaria sinensis

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期刊论文

作者：

Yuan, Hanwen;Zhao, Jianping;Wang, Mei;Khan, Shabana I.;Zhai, Chunmei;...

通讯作者：

Wang, Wei;Khan, Ikhlas A.

作者机构：

[Peng, Caiyun; Wang, Wei; Huang, Jianhua; Xiong, Guanghua; Yuan, Hanwen] Hunan Univ Chinese Med, Sch Pharm, Sino Pakistan TCM & Ethnomed Res Ctr, TCM & Edmomed Innovat & Dev Lab, Changsha 410208, Hunan, Peoples R China.

[Zhai, Chunmei; Khan, Shabana I.; Zhao, Jianping; Wang, Mei; Yuan, Hanwen; Khan, Ikhlas A.] Univ Mississippi, Sch Pharm, Res Inst Pharmaceut Sci, Natl Ctr Nat Prod Res, University, MS 38677 USA.

[Zhai, Chunmei] Heilongjiang Univ Chinese Med, Harbin 2193442, Heilongjiang, Peoples R China.

[Xu, Qiongming] Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China.

通讯机构：

[Wang, Wei] H

[Khan, Ikhlas A.] U

Hunan Univ Chinese Med, Sch Pharm, Sino Pakistan TCM & Ethnomed Res Ctr, TCM & Edmomed Innovat & Dev Lab, Changsha 410208, Hunan, Peoples R China.

Univ Mississippi, Sch Pharm, Res Inst Pharmaceut Sci, Natl Ctr Nat Prod Res, University, MS 38677 USA.

语种：

英文

关键词：

Aquilaria sinensis;Thymelaeaceae;Benzophenone glycosides;Structure elucidation;NMR

期刊：

Fitoterapia

ISSN：

1971-551X

年：

2017

卷：

121

页码：

170-174

DOI：

10.1016/j.fitote.2017.07.013

基金类别：

United States Department of Agriculture, Discovery & Development of Natural Products for Pharmaceutical & Agricultural Applications [58-6060-6-015]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81374062, 85673179]

机构署名：

本校为第一且通讯机构

院系归属：

药学院

摘要：

Four new benzophenone glycosides named as aquilaside A–D (1–4) along with five known compounds (5–9) were isolated from the methanol extract of the flower buds of Aquilaria sinensis. Their structures were elucidated on the basis of 1D and 2D NMR and mass spectroscopic analyses. All purified compounds were evaluated for their anti-inflammatory and cytotoxic activities. Aquilasides B and C displayed moderate cytotoxicity against SK-MEL cells with IC50 of 17.0 and 12.0 μM and weak NF-κB inhibitive activity at 100 ...

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Benzophenone glycosides from the flower buds of Aquilaria sinensis

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