Screening and identifying antioxidants from Oplopanax elatus using 2,2 \'-diphenyl-1-picrylhydrazyl with off-line two-dimensional HPLC coupled with diode array detection and tandem time-of-flight mass spectrometry - 成果

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Screening and identifying antioxidants from Oplopanax elatus using 2,2 '-diphenyl-1-picrylhydrazyl with off-line two-dimensional HPLC coupled with diode array detection and tandem time-of-flight mass spectrometry

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成果类型：

期刊论文

作者：

Shao, Li;Nie, Ming-Kun;Chen, Man-Yun;Wang, Jin;Wang, Chong-Zhi;...

通讯作者：

Huang, Wei-Hua

作者机构：

[Shao, Li] Hunan Univ Chinese Med, Sch Pharm, Dept Pharmacognosy, Changsha, Hunan, Peoples R China.

[Huang, Wei-Hua; Nie, Ming-Kun; Wang, Jin; Zhou, Hong-Hao; Chen, Man-Yun] Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China.

[Huang, Wei-Hua; Nie, Ming-Kun; Wang, Jin; Zhou, Hong-Hao; Chen, Man-Yun] Cent S Univ, Inst Clin Pharmacol, Changsha, Hunan, Peoples R China.

[Huang, Wei-Hua; Nie, Ming-Kun; Wang, Jin; Zhou, Hong-Hao; Chen, Man-Yun] Cent S Univ, Hunan Key Lab Pharmacogenet, Changsha, Hunan, Peoples R China.

[Huang, Wei-Hua; Yuan, Chun-Su] Univ Chicago, Pritzker Sch Med, Tang Ctr Herbal Med Res, Chicago, IL 60637 USA.

通讯机构：

[Huang, Wei-Hua] C

Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

Antioxidants;Oplopanax;Oplopanax elatus;Phenolics

期刊：

Journal of Separation Science

ISSN：

1615-9306

年：

2016

卷：

期：

页码：

4269-4280

DOI：

10.1002/jssc.201600838

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31400306]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2015JJ3156]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2015M570692]; fundamental research funds for the central universities of Central South University [1681-7608040003]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [AT004418, AT005362]

机构署名：

本校为第一机构

院系归属：

药学院

摘要：

The root of Oplopanax elatus (Nakai) Nakai has a well-known history of use for the treatment of diseases such as neurasthenia, cardiovascular disorders, and cancer by the native people in northeast China. It is important to screen and identify the bioactive molecules from its root rapidly. Hereby, an off-line two-dimensional high performance liquid chromatography coupled with diode array detection and tandem time-of-flight mass spectrometry together with 2,2ʹ-diphenyl-1-picrylhydrazyl was established to screen antioxidants from the root of O. elatus. A Waters cyanogen column (150 ×3...

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Screening and identifying antioxidants from Oplopanax elatus using 2,2 '-diphenyl-1-picrylhydrazyl with off-line two-dimensional HPLC coupled with diode array detection and tandem time-of-flight mass spectrometry

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