Effect of Danhong injection on heart failure in rats evaluated by metabolomics

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成果类型：

期刊论文

作者：

Li, Lin;Zhong, Senjie;Ye, Jiahao;Hu, Siyuan;Hu, Zhixi

通讯作者：

Hu, ZX

作者机构：

[Hu, Zhixi; Li, Lin; Hu, ZX; Hu, Siyuan] Hunan Univ Chinese Med, Domest class Discipline Construct Project Chinese, Changsha, Hunan, Peoples R China.

[Hu, Zhixi; Li, Lin; Hu, ZX] Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Changsha, Hunan, Peoples R China.

[Li, Lin] Hunan Engn Technol Res Ctr Med & Funct Food, Changsha, Hunan, Peoples R China.

[Zhong, Senjie; Ye, Jiahao] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China.

[Ye, Jiahao] Hunan Univ Chinese Med, Postgrad Sch, Changsha, Hunan, Peoples R China.

通讯机构：

[Hu, ZX ] H

Hunan Univ Chinese Med, Domest class Discipline Construct Project Chinese, Changsha, Hunan, Peoples R China.

Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Heart Failure;Danhong injection;Metabolomics;transverse aortic constriction;Chinese medicine (CM)

期刊：

Frontiers in Medicine

ISSN：

2296-858X

年：

2023

卷：

页码：

1259182

DOI：

10.3389/fmed.2023.1259182

基金类别：

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. Funding for this research was provided by National Natural Science Foundation of China (grant number 82274412), the National Natural Scie [82274412]; National Natural Science Foundation of China [kq2208185]; National Natural Science Foundation of Changsha [B2023045]; Hunan Provincial scientific research project of traditional Chinese Medicine

机构署名：

本校为第一机构

院系归属：

中医学院

研究生院

中医诊断研究所

摘要：

BackgroundHeart failure (HF) is characterized by reduced ventricular filling or ejection function due to organic or non-organic cardiovascular diseases. Danhong injection (DHI) is a medicinal material used clinically to treat HF for many years in China. Although prior research has shown that Danhong injection can improve cardiac function and structure, the biological mechanism has yet to be determined.MethodsSerum metabolic analysis was conducted via ultra-high-performance liquid chromatography-quadrupole time-of-flight/mass spectrometry (UHPLC-QE/MS) to explore underlying protective mechanism...

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Effect of Danhong injection on heart failure in rats evaluated by metabolomics

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