Maresin 1 Activates LGR6 to Alleviate Neuroinflammation via the CREB/JMJD3/IRF4 Pathway in a Rat Model of Subarachnoid Hemorrhage

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成果类型：

期刊论文

作者：

Li, Zhenyan;Yuan, Wen;Yang, Xian;Jiang, Juan;Zhang, Qi-Lei;...

通讯作者：

Zuo, YC

作者机构：

[Zuo, Yu-Chun; Li, Zhenyan] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Peoples R China.

[Yuan, Wen] Cent South Univ, Zhuzhou Cent Hosp, Dept Neurosurg, Zhuzhou Hosp,Xiangya Sch Med, Zhuzhou 412007, Peoples R China.

[Yang, Xian] Hunan Univ Chinese Med, Hosp 1, Dept Dermatol, Changsha 410007, Peoples R China.

[Jiang, Juan; Zhang, Qi-Lei; Yan, Xiao-Xin] Cent South Univ, Xiangya Sch Med, Dept Anat & Neurobiol, Changsha 410013, Peoples R China.

[Zuo, Yu-Chun; Zuo, YC] Cent South Univ, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410008, Peoples R China.

通讯机构：

[Zuo, YC ] C

Cent South Univ, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410008, Peoples R China.

语种：

英文

关键词：

interferon regulatory factor 4;leucine-rich repeat containing G protein–coupled receptor 6;maresin 1;neuroinflammation;subarachnoid hemorrhage

期刊：

Neuroscience

ISSN：

0306-4522

年：

2024

卷：

542

页码：

21-32

DOI：

10.1016/j.neuroscience.2024.01.022

基金类别：

CRediT Author Contribution Statement Zhenyan Li: Conceptualization, Data curation, Writing original draft. Wen Yuan: Investigation, Data curation. Xian Yang: Investigation, Data curation. Juan Jiang: Investigation, Data curation. Qi-Lei Zhang: Investigation. Xiao-Xin Yan: Writing – review & editing, Methodology. Yu-Chun Zuo: Conceptualization, acquisition, Data curation, Writing original draft.

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

is an early event of brain injury after subarachnoid hemorrhage (SAH). Whether the macrophage mediators in resolving inflammation 1 (MaR1) is involved in SAH pathogenesis is unknown. In this study, 205 male Sprague-Dawley rats were subjected to SAH via endovascular perforation in the experimental and control groups. MaR1 was dosed intranasally at 1 h after SAH, with LGR6 siRNA and KG -501, GSK-J4 administered to determine the signaling pathway. Neurobehavioral, histological and biochemical data were obtained from the animal groups with designated treatments. The results showed: (i) The leucine...

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Maresin 1 Activates LGR6 to Alleviate Neuroinflammation via the CREB/JMJD3/IRF4 Pathway in a Rat Model of Subarachnoid Hemorrhage

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