期刊论文

Investigation on the function mechanism of cornus officinalis and polygonum cuspidatum in the treatment of triple negative breast cancer based on network pharmacology and molecular docking

中文

中国医药科学

2095-0616

2023

13

14

76-81

10.20116/j.issn2095-0616.2023.14.18

重庆市科研机构绩效激励引导专项项目(jxyn2021-2-27)。

本校为第一机构

目的 利用网络药理学方法结合分子对接探究山茱萸-虎杖药对治疗三阴性乳腺癌的作用机制。方法采用TCMSP数据库获取药物的化学成分及其相关靶点；选择Gene Cards和OMIM数据库收集疾病的相关靶点，筛选出二者的共同靶点后可绘制蛋白质互作（PPI）网络；对关键靶点进行基因本体（GO）功能富集分析和京都基因组与基因组百科全书通路（KEGG）通路富集分析，最后进行分子对接验证。结果 筛选得到药物有效成分共20个；疾病相关靶点1512个，与药物共同靶点47个。通过PPI网络得出ESR1、EGFR和PTGS2为关键靶点。GO通路和KEGG富集分析显示，山茱萸-虎杖药对通过参与多种生物学过程抗三阴性乳腺癌；通过PI3K...

Objective To investigate the function mechanism of cornus officinalis and polygonum cuspidatum in the treatment of triple negative breast cancer based on network pharmacology and molecular docking.Methods The chemical components of drugs and their relevant targets were ...MORE Objective To investigate the function mechanism of cornus officinalis and polygonum cuspidatum in the treatment of triple negative breast cancer based on network pharmacology and molecular docking.Methods The chemical components of drugs and their relevant targets were obtained by TCMSP database.Gene Cards and OMIM datab...