Mechanisms of fibrinogen trans-activation of the EGFR/Ca2+ signaling axis to regulate mitochondrial transport and energy transfer and inhibit axonal regeneration following cerebral ischemia

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成果类型：

期刊论文

作者：

Zhou, Shengqiang;Li, Bo;Wu, Dahua;Chen, Yanjun;Zeng, Wen;...

通讯作者：

Liu, F

作者机构：

[Zhou, Shengqiang; Liu, Fang] Hunan Acad Tradit Chinese Med, Hunan Prov Hosp Integrated Tradit Chinese & Wester, Affiliated Hosp, Natl TCM Master Liu Zuyi Inheritance Studio, 58 Lushan Rd, Changsha 410006, Hunan, Peoples R China.

[Li, Bo] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Pediat, Changsha, Hunan, Peoples R China.

[Wu, Dahua] Hunan Acad Tradit Chinese Med, Hunan Prov Hosp Integrated Tradit Chinese & Wester, Affiliated Hosp, Dept Neurol, Changsha, Hunan, Peoples R China.

[Chen, Yanjun; Tan, Lingjuan; Zeng, Wen; Huang, Jia] Hunan Univ Chinese Med, Grad Sch, Changsha, Hunan, Peoples R China.

[Mao, Guo] Hunan Acad Tradit Chinese Med, Hunan Prov Hosp Integrated Tradit Chinese & Wester, Affiliated Hosp, Key Project Off, Changsha, Hunan, Peoples R China.

通讯机构：

[Liu, F ] H

Hunan Acad Tradit Chinese Med, Hunan Prov Hosp Integrated Tradit Chinese & Wester, Affiliated Hosp, Natl TCM Master Liu Zuyi Inheritance Studio, 58 Lushan Rd, Changsha 410006, Hunan, Peoples R China.

语种：

英文

关键词：

EGFR/Ca2+ signaling;axonal regeneration;fibrinogen;middle cerebral artery occlusion;neuronal energy crisis

期刊：

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

ISSN：

0022-3069

年：

2025

卷：

期：

页码：

210-222

DOI：

10.1093/jnen/nlae114

基金类别：

Natural Science Foundation of Hunan Province [2023JJ60458, 2023JJ30367]; Scientific Research Project of Hunan Provincial Health Commission [D202319019427]; Natural Science Foundation Project of Changsha City [kq2208144]; Clinical Medical Technology Innovation Guidance Project of Hunan Province [2021SK51010]; Scientific Research Project of Hunan Provincial Administration of Traditional Chinese Medicine [C2022011]; Academic Inheritance and Communication Project of China Academy of Chinese Medical Sciences [CI2022E014XB]

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

研究生院

摘要：

Ischemic stroke results in inhibition of axonal regeneration but the roles of fibrinogen (Fg) in neuronal signaling and energy crises in experimental stroke are under-investigated. We explored the mechanism of Fg modulation of axonal regeneration and neuronal energy crisis after cerebral ischemia using a permanent middle cerebral artery occlusion (MCAO) rat model and primary cortical neurons under low glucose-low oxygen. Behavioral tests assessed neurological deficits; immunofluorescence, immunohistochemistry, and Western-blot analyzed Fg and protein levels. Fluo-3/AM fluorescence measured fre...

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Mechanisms of fibrinogen trans-activation of the EGFR/Ca2+ signaling axis to regulate mitochondrial transport and energy transfer and inhibit axonal regeneration following cerebral ischemia

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