期刊论文

Occurrence and clinical treatment of epilepsy associated with gene mutation in voltage-gated sodium channel subtypes

中文

中国临床药理学与治疗学

Chinese Journal of Clinical Pharmacology and Therapeutics

1009-2501

2018

23

5

570-577

10.12092/j.issn.1009-2501.2018.05.015

国家自然科学基金资助项目(81503276)； 湖南省自然科学基金资助项目(2018JJ3387)； 湖南省教育厅项目(15C1044)； 湖南省大学生创新性课题(2017-310)； 湖南中医药大学大学生创新性课题(2016-21)；

本校为第一机构

针对污水处理厂尾水TN去除问题,采用16S rDNA克隆文库法,探究了3DBER-S(三维电极生物膜耦合硫自养脱氮工艺)的强化脱氮机制及其菌群特征.结果表明,I(电流)和HRT(水力停留时间)对3DEBR-S中氢自养和硫自养反硝化作用所占比例的影响较大,但对脱氮效率影响不显著.当进水C/N[p(COD_(Cr))/p(TN〕为1、p(NO_3~-N)为35 mg/L、/为300 mA、HRT为4 h时,NO_3~--N和TN去除率可分别稳定在80%和74%以上.16S rDNA克隆文库结果显示,反应器中β变形菌纲为优势菌群,占47.89%〔以OUT(操作单元)计〕.在β变形菌纲中,与具有反硝化功能的陶厄氏菌属(Thuera)相似的细菌所占比例最大,为52.94%;与可分别利用硫和氢为电子供...

Epilepsy is a common brain disease caused by abnormal discharge of brain neurons with a characteristic of short brain dysfunction. It can break out repeatedly,and has a serious influence on the health and quality of life of patients. Previous studies have found that voltage-gated sodium channel subtypes（ Nav1. 1,Nav1. 2,Nav1. 3,Nav1. 6,Nav1. 7） expressed in the central nervous system play an important role in the pathogenesis of epilepsy,and they are targets for related antiepileptic drugs. The mutations in the encoding gene of α-subunit of ...