期刊论文

Liu, Z.

英文

American Journal of Gastroenterology

0002-9270

2021

116

5

1024-1035

10.14309/ajg.0000000000001050

Financial support: This study was supported and funded by the Twelfth Five-Year National Science and Technology Pillar Program (grant 2012BAI24B01) from the Ministry of Science and Technology of the People's Republic of China. The funder of the study had no role in the design and conduct of study, the collection, analysis and interpretation of data, or writing of the report. The corresponding author had full access to all data in the study and the final responsibility for the decision to submit for publication.

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INTRODUCTION:This multicenter, randomized, noninferiority trial compared electroacupuncture with prucalopride for the treatment of severe chronic constipation (SCC).METHODS:Participants with SCC (≤ 2 mean weekly complete spontaneous bowel movements [CSBMs]) were randomly assigned to receive either 28-session electroacupuncture over 8 weeks with follow-up without treatment over 24 weeks or prucalopride (2 mg/d before breakfast) over 32 weeks. The primary outcome was the proportion of participants with ≥3 mean weekly CSBMs over weeks 3-8, based...