Knockdown of LINC01116 inhibits cell migration and invasion in head and neck squamous cell carcinoma through epithelial-mesenchymal transition pathway

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成果类型：

期刊论文

作者：

Wu, Jing;Chen, Zhizhao;Zhang, Li;Cao, Jun;Li, Xiaoyu;...

通讯作者：

Zhang, Shanshan;He, Dong

作者机构：

[Wu, Jing; Li, Xiaoyu; Zhang, Li; Cao, Jun] Peoples Hosp Longhua Shenzhen, Dept Stomatol, Shenzhen, Guangdong, Peoples R China.

[Wu, Jing; Gong, Zhaojian] Cent S Univ, Xiangya Hosp 2, Dept Oral & Maxillofacial Surg, Changsha, Hunan, Peoples R China.

[Chen, Zhizhao] Cent S Univ, Xiangya Hosp 3, Transplantat Ctr, Changsha, Hunan, Peoples R China.

[Bo, Hao] Cent S Univ, Sch Basic Med, Inst Reprod & Stem Cell Engn, Changsha, Hunan, Peoples R China.

[Zhang, Shanshan] Cent S Univ, Xiangya Hosp, Dept Stomatol, 87 Xiangya St, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Zhang, Shanshan] C

[He, Dong] H

Cent S Univ, Xiangya Hosp, Dept Stomatol, 87 Xiangya St, Changsha 410008, Hunan, Peoples R China.

Hunan Univ Chinese Med, Peoples Hosp Hunan Prov 2, Dept Respirat, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

LINC01116;epithelial-mesenchymal transition;squamous cell carcinoma

期刊：

Journal of Cellular Biochemistry

ISSN：

0730-2312

年：

2020

卷：

121

期：

页码：

867-875

DOI：

10.1002/jcb.29331

基金类别：

Special Fund of Clinical Medicine of Chinese Medical Association [17020280697]; Fundamental Research Funds for the Central Universities of Central South University [1053320171023]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2015JJ2191, 2015JJ3161, 2019JJ50308]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81772901, 81803025]

机构署名：

本校为通讯机构

摘要：

Long noncoding RNAs (lncRNAs) are linked to tumor development and progression. The aim of this study was to determine the prognostic significance and biological role of LINC01116 in head and neck squamous cell carcinoma (HNSCC). We identified 21 aberrantly expressed lncRNAs specific to HNSCC that were common in two microarray datasets. LINC01116 was highly overexpressed in HNSCC tissues and was correlated to shorter overall survival and relapse-free survival duration, as analyzed by the online Gene Expression Profiling Interactive Analysis platform. LINC01116 was also overexpressed in oral squ...

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Knockdown of LINC01116 inhibits cell migration and invasion in head and neck squamous cell carcinoma through epithelial-mesenchymal transition pathway

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