期刊论文

Zhou, D.-S.

中文

中国组织工程研究

2095-4344

2016

20

50

7524-7529

10.3969/j.issn.2095-4344.2016.50.011

本校为第一且通讯机构

背景：移植有活力、分化能力强的干细胞修复神经组织来延缓老年痴呆症的发病进程是研究人员的重要目标。　　目的：探讨不同剂量脐带间充质干细胞移植对老年痴呆大鼠学习记忆能力的影响。　　方法：选取50只7月龄SD大鼠随机分为正常组、模型组以及高、中、低剂量脐带间充质干细胞移植组，每组10只。模型组和移植组腹腔注射D-半乳糖150 mg/kg建立老年痴呆模型，正常组腹腔注射生理盐水，连续90 d。收集第3代脐带间充质干细胞，以低、中、高3个剂量(1×105/0.2 mL/20 g、5×105/0.2 mL/20 g、1×106/0.2 mL/20 g)通过尾静脉进行移植，移植45 d后，Morris水迷宫实验检测其学习记忆能力，苏木精-伊红...

BACKGROUND: To delay the onset of Alzheimer’s disease, transplantation of viable and well-differentiated stem cells is expected to repair neural tissue, which has been an issue of concern. OBJECTIVE: To explore the effects of different doses of human umbilical cord mesenchymal stem cells (hUCMSCs) on learning and memory ability of Alzheimer’s disease rats. METHODS: Fifty Sprague-Dawley rats, 7 months of age, were randomized into normal, model, high-, middle- and low-dose hUCMSCs groups (n=10 per group). Rats in model and UCMSCs groups were us...