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Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSIO41301

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成果类型:
期刊论文
作者:
Liu, Nianzhen;Peng, Shuai;Yang, Jie;Cong, Ziwen;Lin, Xiuping;...
通讯作者:
Liu, Yonghong;Wang, Junfeng;Zhou, Xiaojiang
作者机构:
[Zhou, Xuefeng; Peng, Shuai; Liu, Nianzhen; Wang, Junfeng; Liu, Yonghong; Lin, Xiuping; Liao, Shengrong; Yang, Bin; Cong, Ziwen] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China.
[Peng, Shuai; Liu, Nianzhen; Zhou, Xiaojiang] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China.
[Yang, Jie] Southern Med Univ, Guangdong Prov Key Lab New Drug Screening, Guangzhou Key Lab Drug Res Emerging VirusPrevent, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China.
[Liu, Yonghong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
通讯机构:
[Liu, YH; Wang, JF] C
[Zhou, Xiaojiang] H
Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China.
Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China.
语种:
英文
关键词:
Antiviral activity;Aspergillus sydowii;Sesquiterpenoid;Xanthone
期刊:
Fitoterapia
ISSN:
1971-551X
年:
2019
卷:
135
页码:
27-32
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [41776169, 21502204, 21772210]; Special Funds for Promoting Economic Development (Marine Economic Development) of Guangdong Province [GDME-2018C010]; Guangdong Province Public Welfare Research and Capacity Building Project [2016A020222010]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2018A0303130219]; Pearl River S&T Nova Program of Guangzhou [201710010136]; Guangzhou Science and Technology Project [201804010462]
机构署名:
本校为通讯机构
院系归属:
药学院
摘要:
Five new compounds, including one bisabolane-type sesquiterpenoids, namely aspergillusene D (1), two new xanthones (2 and 3), and two new catecholderivatives (4 and 5), together with fourteen known compounds (6-19), were isolated and identified from the fungus Aspergillus sydowiiSCSIO 41,301 from the sponge Phakellia fusca. Their structures and absolute configurations were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. Most of the isolated compounds (1-3, and 6-19) were evaluated for their antiviral, cytotoxic, and antibacterial activities....

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