Biomimetic hybrid-cell membrane nanoparticles loaded with panaxytriol for breast cancer combinational therapy

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成果类型：

期刊论文

作者：

Xie, Qian;Li, Bin;Fan, Jialong;Liang, Jiahao;Jiang, Sai;...

通讯作者：

Bin Li<&wdkj&>Bin Liu<&wdkj&>Wei Wang

作者机构：

[Liu, Bin; Qin, Yan; Nie, Xiaoping; Li, Bin; Cui, Jiao; Wang, Wei; Jiang, Sai; Sun, Shaoqiu; Xie, Qian; Jiang, Ling] Hunan Univ Chinese Med, Innovat Mat Med Res Inst, Sch Pharm, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Peoples R China.

[Liu, Bin; Qin, Yan; Nie, Xiaoping; Fan, Jialong] Hunan Univ, Coll Biol, Changsha 410082, Peoples R China.

[Liang, Jiahao] Dalian Med Univ, Coll Pharm, Coll Integrat Med, Dalian 116044, Peoples R China.

[Nie, Xiaoping; Cui, Jiao; Sun, Shaoqiu] Hunan Univ Chinese Med, Affiliated Hosp 2, Changsha 410005, Peoples R China.

[Xie, Qian] Hunan Provincial Maternal & Child Hlth Care Hosp, Changsha 410008, Peoples R China.

通讯机构：

[Bin Li; Bin Liu; Wei Wang] T

TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China<&wdkj&>TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China<&wdkj&>College of Biology, Hunan University, Changsha 410082, China<&wdkj&>TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China

语种：

英文

关键词：

Breast cancer;Panaxytriol;Prussian blue;Hybrid-cell membrane;Panax japonicus

期刊：

Materials & Design

ISSN：

0264-1275

年：

2022

卷：

223

页码：

111219

DOI：

10.1016/j.matdes.2022.111219

基金类别：

National Natural Science Foundation of China; Natural Science Foundation of Hunan Province; Research Foundation of the Education Bureau of Hunan Province; Opening foundation of Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province; Hunan Administration of TCM; [81703819]; [82074122]; [2020JJ4463]; [20A367]; [2022CG01]; [Xiangcai2021-105]

机构署名：

本校为第一机构

院系归属：

第二中医临床医学院

药学院

摘要：

Breast cancer is the most prevalent cancer with an unfavorable prognosis in women, which seriously threatened women's health worldwide. In our previous study, a phytoconstituent, panaxytriol (PA), iso-lated from a Tujia ethnomedicine Panax japonicus, showed excellent inhibitory effects on APE1 activity, an enzyme tightly related with the development of breast cancer. Considering the tumor cell-killing ability and poor bioavailability of PA in vivo, Prussian blue nanoparticles with dopamine surface modification were applied to enhance its therapeutic efficacy against breast cancer by combining ...

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Biomimetic hybrid-cell membrane nanoparticles loaded with panaxytriol for breast cancer combinational therapy

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