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New dawn for cancer cell death: Emerging role of lipid metabolism

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成果类型:
期刊论文
作者:
Zhang, Chanjuan;Zhu, Neng;Li, Hongfang;Gong, Yongzhen;Gu, Jia;...
通讯作者:
Qin, L.;Dai, A.;Wang, W.
作者机构:
[Li, Hongfang; Gong, Yongzhen; Shi, Yaning; Liao, Duanfang; Gu, Jia; Zhang, Chanjuan; Qin, Li] Hunan Univ Chinese Med, Sch Pharm, Lab Stem Cell Regulat Chinese Med & Its Applicat, Changsha 410208, Hunan, Peoples R China.
[Wang, Wei; Zhang, Chanjuan] Hunan Univ Chinese Med, Innovat Mat Med Res Inst, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Hunan, Peoples R China.
[Zhu, Neng] Hunan Univ Chinese Med, Hosp 1, Changsha 410021, Hunan, Peoples R China.
[Dai, Aiguo; Qin, Li] Hunan Univ Chinese Med, Inst Key Lab Vasc Biol & Translat Med Hunan Prov, Changsha 410208, Hunan, Peoples R China.
[Qin, Li] Hunan Univ Chinese Med, Hunan Prov Engn Res Ctr Bioact Subst Discovery Tr, Changsha 410208, Hunan, Peoples R China.
通讯机构:
[Wei Wang] T
[Aiguo Dai] I
[Li Qin] L
TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, PR China<&wdkj&>Institutional Key Laboratory of Vascular Biology and Translational Medicine in Hunan Province, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, PR China<&wdkj&>Laboratory of Stem Cell Regulation with Chinese Medicine and Its Application, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, PR China<&wdkj&>Institutional Key Laboratory of Vascular Biology and Translational Medicine in Hunan Province, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, PR China<&wdkj&>Hunan Province Engineering Research Center of Bioactive Substance Discovery of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, PR China
语种:
英文
关键词:
Lipid metabolism;Cancer;Cell death;Therapeutic strategy
期刊:
Molecular Metabolism
ISSN:
2212-8778
年:
2022
卷:
63
页码:
101529
基金类别:
This work was supported by the National Natural Sciences Foundation of China ( 81973668 , 81774130 ), Key Project of the Educational Department of Hunan Province ( 20A375 ), Scientific Research Project of Changsha Science and Technology Bureau ( kq2004060 ), Key Guidance Project of Hunan Provincial Health Commission ( 202213055529 ), Science-Pharmacy Joint Fund of the Natural Science Foundation of Hunan Province , Hunan University of Chinese Medicine Innovation Foundation for Postgraduate ( 2021CX08 ) and the First-Class Discipline of Pharmaceutical Science of Hunan .
机构署名:
本校为第一机构
院系归属:
第一中医临床学院
药学院
摘要:
Background: Resistance to cell death, a protective mechanism for removing damaged cells, is a “Hallmark of Cancer” that is essential for cancer progression. Increasing attention to cancer lipid metabolism has revealed a number of pathways that induce cancer cell death. Scope of review: We summarize emerging concepts regarding lipid metabolic reprogramming in cancer that is mainly involved in lipid uptake and trafficking, de novo synthesis and esterification, fatty acid synthesis and oxidation, lipogenesis, and lipolysis. During carcinogenesis...

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