Integrating systematic biological and proteomics strategies to explore the pharmacological mechanism of danshen yin modified on atherosclerosis

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成果类型：

期刊论文

作者：

Yang, Kailin;Zeng, Liuting*;Ge, Anqi;Pan, Xiaoping;Bao, Tingting;...

通讯作者：

Zeng, Liuting;Ge, Jinwen;Huang, Zhengde

作者机构：

[Yang, Kailin; Ge, Anqi] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha, Peoples R China.

[Tong, Qiaozhen; Pan, Xiaoping; Yang, Kailin; Ge, Anqi; Ge, Jinwen; Huang, Zhengde; Zeng, LT; Ge, JN; Huang, ZD] Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.

[Yang, Kailin] Capital Med Univ, Beijing, Peoples R China.

[Zeng, Liuting] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Rheumatol & Clin Immunol, Beijing, Peoples R China.

[Bao, Tingting] China Acad Chinese Med Sci, Guanganmen Hosp, Beijing, Peoples R China.

通讯机构：

[Zeng, LT; Ge, JN; Huang, ZD] H

Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

ApoE-/- mouse;atherosclerosis;Danshen Yin Modified;proteomics;reverse transcription-PCR;systematic biology

期刊：

Journal of Cellular and Molecular Medicine

ISSN：

1582-1838

年：

2020

卷：

期：

页码：

13876-13898

DOI：

10.1111/jcmm.15979

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81774174]

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

摘要：

This research utilized the systematic biological and proteomics strategies to explore the regulatory mechanism of Danshen Yin Modified (DSYM) on atherosclerosis (AS) biological network. The traditional Chinese medicine database and HPLC was used to find the active compounds of DSYM, Pharmmapper database was used to predict potential targets, and OMIM database and GeneCards database were used to collect AS targets. String database was utilized to obtain the other protein of proteomics proteins and the protein-protein interaction (PPI) data of DSYM targets, AS genes, proteomics proteins and othe...

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Integrating systematic biological and proteomics strategies to explore the pharmacological mechanism of danshen yin modified on atherosclerosis

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