Establishment of a novel myocarditis mouse model based on cyclosporine A

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成果类型：

期刊论文

作者：

Zhao, Tian Hao;Jiang, Yi Xuan;Chen, Kai Qin;Qiu, Dan;Xu, Yan Zhe;...

通讯作者：

Ke Wei

作者机构：

[Zhao, Tian Hao; Ye, Chun; Xu, Yan Zhe; Jiang, Yi Xuan; Zhou, Fang Liang; Qiu, Dan; Ren, Ting; Dai, Bin; Zhang, Bo; Hu, Jue; Lu, Jun; Wei, Ke; Xiao, Rong; Lu, Fang Guo; Chen, Kai Qin] Hunan Univ Chinese Med, Med Coll, Changsha 410208, Hunan, Peoples R China.

[Hu, Jue; Wei, Ke; Lu, Fang Guo] Hunan Univ Chinese Med, Hunan Prov Key Lab Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Ke Wei] M

Medical College, Hunan University of Chinese Medicine, Changsha, China<&wdkj&>Hunan Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, China

语种：

英文

关键词：

Myocarditis;Cyclosporin A;Mouse model;Bioinformatics;Signaling pathway;Genes

期刊：

Genes & Genomics

ISSN：

1976-9571

年：

2022

卷：

期：

页码：

1593-1605

DOI：

10.1007/s13258-022-01267-4

基金类别：

National Natural Science Foundation of China [82074250]; Natural Science Foundation of Hunan Province [2021JJ30508, 2020JJ4063]; Hunan Province Chinese Medicine Research Program Project [2021055]; Changsha Outstanding Innovative Youth Training Program [kq2009070]; Key Discipline of Hunan University of Traditional Chinese Medicine, Excellent Teaching Team for Postgraduates in Hunan Province; Hunan University Student Innovation and Entrepreneurship Training Program [S202110541048]

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

BACKGROUND: Myocarditis is a myocardial injury that can easily cause adolescent death. Traditional research models of animal invasion with viral components, lipopolysaccharide (LPS) or porcine myocardial myosin, among others, have the shortcomings of potential biological safety hazards and high animal mortality. OBJECTIVE: To explore the construction of a novel myocarditis model with cyclosporine A and the potential genes and pathways associated with it. METHODS: BALB/c mice were used in this study, and cyclosporin A and LPS were injected into the peritoneal cavity of mice. The successful esta...

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Establishment of a novel myocarditis mouse model based on cyclosporine A

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