期刊论文

Liu, Lijuan;Zhou, Desheng;Yan, SY

英文

Phytomedicine

0944-7113

2025

136

156331

10.1016/j.phymed.2024.156331

CRediT authorship contribution statement Cuilan Gong: Writing – review & editing, Project administration, Investigation, acquisition, Conceptualization. Xinying Fu: Writing – review & editing, Writing – original draft, Methodology, Investigation, Data curation. Qiang Ma: Writing – original draft, Software, Methodology. Menghao He: Software, acquisition, Data curation. Xinhua Zhu: Writing – review & editing, Supervision, acquisition. Lijuan Liu: Writing – review & editing, Project administration, This study was supported by the National Natural Science Foundation of China ( 82104766 ), the Natural Science Foundation of Hunan Province ( 2024JJ5313 , 2023JJ40512 , 2022JJ30088 ), Hunan Provincial Health Commission Guiding Project ( 202203074864 , W20243137 ), Joint Project of the Administration of Traditional Chinese Medicine and Municipalities ( D2024031 ), the University-level Fund Project of Hunan University of Chinese Medicine ( 2022XYLH016 ). Healthy China - Buchang Zhiyuan Heart and Brain Health

本校为第一且通讯机构

Ischemic stroke ranks as the second leading cause of global mortality and disability. Although reperfusion is crucial for salvaging brain tissue, it carries the risk of secondary injuries, such as ferroptosis. Gastrodin, a neuroprotective compound found in Chinese herbal medicine, may regulate this process. However, its impact on stroke-induced ferroptosis remains unclear. Objective: This research endeavors to probe Gastrodin's influence on post-ischemic ferroptosis, deciphering its mechanisms and assessing its therapeutic promise. Methods: We developed rat models of middle cerebral artery occ...