Impaired Self-Renewal and Increased Colitis and Dysplastic Lesions in Colonic Mucosa of AKR1B8-Deficient Mice

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Shen, Yi;Ma, Jun;Yan, Ruilan;Ling, Hongyan;Li, Xiaoning;...

通讯作者：

Cao, DL

作者机构：

[Shen, Yi; Ma, Jun; Yan, Ruilan; Ling, Hongyan; Li, Xiaoning; Huang, Chenfei; Bu, Yiwen; Cao, Yu; Wan, Laxiang; Zu, Xuyu; Liu, Jianghua] So Illinois Univ, Sch Med, Simmons Canc Inst, Dept Med Microbiol Immunol & Cell Biol, Springfield, IL 62794 USA.

[Yang, Wancai] Univ Illinois, Dept Pathol, Chicago, IL USA.

[Gao, John] So Illinois Univ, Sch Med, Dept Pathol, Springfield, IL 62794 USA.

[He, Yingchun; Liao, Duan-Fang] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha, Hunan, Peoples R China.

[Huang, Mei Chris] So Illinois Univ, Sch Med, Div Gastroenterol, Springfield, IL 62794 USA.

通讯机构：

[Cao, DL ] S

So Illinois Univ, Sch Med, Simmons Canc Inst, Dept Med Microbiol Immunol & Cell Biol, 913 N Rutledge St, Springfield, IL 62794 USA.

语种：

英文

期刊：

Clinical Cancer Research

ISSN：

1078-0432

年：

2015

卷：

期：

页码：

1466-1476

DOI：

10.1158/1078-0432.CCR-14-2072

基金类别：

National Cancer Institute [CA122622]; NIH [DK33165]

机构署名：

本校为其他机构

院系归属：

医学院

药学院

摘要：

Abstract Purpose: Ulcerative colitis and colitis-associated colorectal cancer (CAC) is a serious health issue, but etiopathological factors remain unclear. Aldo-keto reductase 1B10 (AKR1B10) is specifically expressed in the colonic epithelium, but downregulated in colorectal cancer. This study was aimed to investigate the etiopathogenic role of AKR1B10 in ulcerative colitis and CAC. Experimental Design: Ulcerative colitis and CAC biopsies (paraffin-embedded sections) and frozen tissues were collected to examine AKR1B10 expression. Aldo-keto r...

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Impaired Self-Renewal and Increased Colitis and Dysplastic Lesions in Colonic Mucosa of AKR1B8-Deficient Mice

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