期刊论文

Cao, Deliang

英文

Clinical Cancer Research

1078-0432

2015

21

6

1466-1476

10.1158/1078-0432.CCR-14-2072

National Cancer InstituteUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [CA122622]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [DK33165]; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [R21CA122622, R21CA122622] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [R01DK033165, R37DK033165, R01DK033165, R37DK033165, R37DK033165, R01DK033165, R01DK033165, R37DK033165, R01DK033165, R37DK033165, R01DK033165, R37DK033165, R01DK033165, R37DK033165, R37DK033165, R01DK033165, R01DK033165, R01DK033165, R01DK033165, R37DK033165, R01DK033165, R37DK033165, R01DK033165, R01DK033165, R01DK033165, R01DK033165, R01DK033165, R01DK033165, R01DK033165, R01DK033165, R01DK033165] Funding Source: NIH RePORTER

本校为其他机构

Purpose: Ulcerative colitis and colitis-associated colorectal cancer (CAC) is a serious health issue, but etiopathological factors remain unclear. Aldo-keto reductase 1B10 (AKR1B10) is specifically expressed in the colonic epithelium, but downregulated in colorectal cancer. This study was aimed to investigate the etiopathogenic role of AKR1B10 in ulcerative colitis and CAC. Experimental Design: Ulcerative colitis and CAC biopsies (paraffin-embedded sections) and frozen tissues were collected to examine AKR1B10 expression. Aldo-keto reductase 1B...