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Gene Expression Network Analysis Identifies Potential Targets for Prevention of Preeclampsia

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成果类型:
期刊论文
作者:
Xia, Yu;Zhao, Yu-Dong;Sun, Gui-Xiang*;Xia, Shuai-Shuai;Yang, Zheng-Wang
通讯作者:
Sun, Gui-Xiang
作者机构:
[Sun, Gui-Xiang; Xia, Shuai-Shuai; Xia, Yu] Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.
[Sun, Gui-Xiang; Xia, Yu] Hunan Univ Chinese Med, Inst Chinese Med Diag, Changsha 410208, Hunan, Peoples R China.
[Yang, Zheng-Wang; Xia, Yu] Hunan Univ Chinese Med, Hosp 1, Dept Obstet & Gynecol, Changsha 410007, Hunan, Peoples R China.
[Zhao, Yu-Dong] Chengdu Univ Tradit Chinese Med, Sch Clin Med, Chengdu 610075, Peoples R China.
通讯机构:
[Sun, Gui-Xiang] H
Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.
语种:
英文
关键词:
preeclampsia;SASH1;PIK3CB;FLT-1;MAPK signaling pathway;Rap1 signaling pathway
期刊:
International Journal of General Medicine
ISSN:
1178-7074
年:
2022
卷:
15
页码:
1023-1032
基金类别:
Special funds for traditional Chinese medicine subsidized by the central government of the State Administration of traditional Chinese Medicine [[2015] 78]
机构署名:
本校为第一且通讯机构
院系归属:
中医学院
第一中医临床学院
中医诊断研究所
摘要:
Objective: Preeclampsia (PE) is a pregnancy-specific multisystem disease as well as an important cause of maternal and perinatal death. This study aimed to analyze the placental transcriptional data and clinical information of PE patients available in the published database and predict the target genes for prevention of PE. Methods: The clinical information and corresponding RNA data of PE patients were downloaded from the GEO database. Cluster analysis was performed to examine the correlation between different genotyping genes and clinical man...

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