期刊论文

中文

新乡医学院学报

1004-7239

2013

30

2

93-95

湖南省教育厅基金资助项目（编号:10C1036）； 湖南中医药大学中药学重点学科项目；

本校为第一机构

目的观察中药复方滋肾益脑方对抑郁大鼠子宫、卵巢形态学的影响。方法将40只大鼠随机分为正常对照组、模型组、氟西汀组、滋肾益脑方中剂量组和高剂量组,采用甲状腺素灌胃和慢性不可预见性应激方法制备肾阴虚抑郁动物模型,采用苏木精-伊红染色法光镜下观察各组大鼠子宫、卵巢的形态学变化。结果与正常对照组比较,模型组显示闭锁卵泡多,黄体和成熟卵泡少见,子宫内膜明显较薄,间质纤维增生;与模型组比较,氟西汀组大鼠子宫、卵巢的形态学变化无明显改善,而滋肾益脑方组子宫、卵巢的病理形态学变化均有不同程度的减轻,其中滋肾益脑方高剂量组较滋肾益脑方中剂量组改善更为明显。结论滋肾益脑方能明显...

Objective To explore the effects of Zishenyinao prescription on morphology of womb and ovary in rat model of depression. Methods Forty rats were randomly divided into normal control group, model group, the fluoxetine group, medi- um dose Zishenyinao group and high-dose Zishenyinao group. The depression with kidney yin difficiency rat model was made by thyrine intragastric administration combined chronicity non-precognition stress methods. The morphology of womb and ovary of rats in each group were observed by hematoxylin-eosin staining under light microscope. Results Compared with normal contr...