期刊论文

Effect and mechanism of electroacupuncture promoting Jiawei Shaoyao Gancao Decoction to alleviate spasticity in rats with cerebral apoplexy improve neurotrophic factors and synaptic plasticity protein for better “brain plasticity”in SCA rats

中文

北京中医药大学学报

1006-2157

2021

44

08

753-763

10.3969/j.issn.1006-2157.2021.08.012

No.81673886:国家自然科学基金 No.2018JJ2294:湖南省自然科学基金 No.201862:湖南省中医药科研项目 No.19B438:湖南省教育厅优秀青年项目 No.XT2020025:宁夏医科大学校级项目

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目的探讨电针联和加味芍药甘草汤对脑卒中痉挛状态(SCA)大鼠神经营养因子及突触可塑性相关蛋白的影响。方法通过两次随机分组,分为空白组、假手术组、模型组、针药组、加味芍药甘草汤组、电针组、巴氯芬组,遴选合格的SD大鼠入组,每组9只。采用改良Zea-Longa线栓法联合内囊注射N-甲基-D-天冬氨酸受体法制备脑卒中肢体痉挛大鼠模型,行为学评分确认模型成功后,分别对电针组(双侧阳陵泉、曲池行电针,1次30 min,1次/d,持续5 d) 、加味芍药甘草汤组(加味芍药甘草汤水煎剂1 d/次,1次100 g/kg体质量,持续5 d) 、巴氯芬组(巴氯芬片水溶液1 d/次,1次2.7 g/kg体质量,持续5 d) 、针药组(加味芍药甘草汤灌服,...

Objective To explore the effects and mechanism of electroacupuncture and Jiawei Shaoyao Gancao (Supplemented Peony and Licorice) Decoction to alleviate spasticity of cerebral apoplexy (SCA). Methods Qualified SD rats were selected to form into the blank group,sham operation group, model group, electroacupuncture group, Jiawei Shaoyao Gancao (JSG) Decoction group, electroacupuncture + JSG group,and baclofen group (n = 9). The improved Zea-Longa thread method and internal capsule injection of the NMDA receptor method were used to prepare a stroke rat model with limb spasticity. After the success...