Epigenetic nanoplatform for synergistic immune activation and immunogenicity restoration enhancing cancer radio-immunotherapy

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成果类型：

期刊论文

作者：

He, Zhenhu;Peng, Xiaopei;Li, Jiong;Zhu, Yaning;Zhang, Xuan;...

通讯作者：

Rong, PF

作者机构：

[Duan, Junhong; Ni, Jing; Li, Jiong; Zhang, Xuan; Peng, Xiaopei; Rong, Pengfei; He, Zhenhu; Zhu, Yaning] Cent South Univ, Xiangya Hosp 3, Dept Radiol, Changsha 410013, Peoples R China.

[Ma, Mengtian] Hunan Univ Chinese Med, Hosp 1, Dept Radiol, Changsha 410013, Peoples R China.

[Wang, Juan; Liu, Zhenguo] Cent South Univ, Xiangya Hosp 3, Dept Infect Dis, Changsha 410013, Peoples R China.

[Feng, Bin; Zeng, Wenbin] Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha 410013, Peoples R China.

[Liu, Chao] Xiamen Univ, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361000, Peoples R China.

通讯机构：

[Rong, PF ] C

Cent South Univ, Xiangya Hosp 3, Dept Radiol, Changsha 410013, Peoples R China.

语种：

英文

关键词：

cGAS-STING pathway;Pyroptosis;GSDME;MHC I;Radio-immunotherapy

期刊：

Chemical Engineering Journal

ISSN：

1385-8947

年：

2025

卷：

508

页码：

161177

DOI：

10.1016/j.cej.2025.161177

基金类别：

National Natural Science Foundation of China [82372072, 82071986]; Key Research and Development Program of Hunan Province [2022SK2025]; Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University [BJ202003]

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

Tumor cells inhibit immune activation pathways and antigen presentation processes through epigenetic silencing mechanisms, thereby lowering the sensitivity of hepatocellular carcinoma (HCC) to radio-immunotherapy. Herein, a tumor-specific, multifunctional nanotherapeutic platform integrating epigenetic regulation with radiotherapy is developed. Radiotherapy activates both cGAS-STING and pyroptosis pathways in HCC cells, while concurrently restoring antigen presentation functions. Specifically, a PEGylated hollow mesoporous MnO 2 (HM-PEG) nanoparticle is loaded with the DNA methylation inhibito...

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Epigenetic nanoplatform for synergistic immune activation and immunogenicity restoration enhancing cancer radio-immunotherapy

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