期刊论文

中文

医学理论与实践

1001-7585

2018

31

14

2045-2047+2058

10.19381/j.issn.1001-7585.2018.14.001

湖南中医药大学大学生创新课题（1022/0001019010）；

本校为第一机构

目的：观察茵陈五苓散对非酒精性脂肪肝病（NAFLD）大鼠Chemerin表达的影响,探讨其对NAFLD的干预作用。方法：SD大鼠按随机数字表法分为正常组和实验组,实验组采用高脂饲料喂养24周造模,随机分为模型组、辛伐他汀对照组和茵陈五苓散高、低剂量组,药物干预6周后分别检测各组大鼠血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）含量,采用ELISA法检测大鼠脂肪因子Chemerin的蛋白表达。结果：与正常组比较,模型组、辛伐他汀组和茵陈五苓散高、低剂量组大鼠血清TC、TG、LDL-C、Chemerin蛋白表达均升高,其中茵陈五苓散高剂量组TC水平未有明显变化（P〉0.05）;与模型组比较,辛伐他汀...

Objective： To observe the effect of Yinchenwuling Powder on expression of Chemerin in rats with non-alcoholic fatty liver,and discuss its intervention effect on NAFLD. Methods： SD rats were divided into normal group and experimental group according to the random number table method. The experimental group was fed with high-fat diet for 24 weeks. The rats were randomly divided into model group,simvastatin control group,and Yinchenwuling Powder high-and low-dose group. 6 weeks after the intervention,serum total cholesterol（ TC）,triglyceride（...