Meranzin hydrate exhibits anti-depressive and prokinetic-like effects through regulation of the shared alpha 2-adrenoceptor in the brain–gut axis of rats in the forced swimming test

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成果类型：

期刊论文

作者：

Xie, Ying;Huang, Xi*;Hu, Sui-yu;Qiu, Xin-jian;Zhang, Ying-jin;...

通讯作者：

Huang, Xi

作者机构：

[Zhang, Chun-hu; Xie, Ying; Huang, Xi; Ren, Ping; He, Juan; Hu, Sui-yu; Wang, Yang; Qiu, Xin-jian; Xie, Wei-bin; Ji, Hui; Zhang, Ying-jin] Cent S Univ, Xiangya Hosp, Inst Integrated Tradit Chinese & Western Med, Lab Ethnopharmacol, Changsha 410008, Hunan, Peoples R China.

[Zhang, Chun-hu; Huang, Xi; Ren, Ping; He, Juan; Hu, Sui-yu; Wang, Yang; Qiu, Xin-jian; Xie, Wei-bin; Ji, Hui; Zhang, Ying-jin] Cent S Univ, Xiangya Hosp, Natl Key Clin Specialist Vocat Sch TCM Encephalop, Changsha 410008, Hunan, Peoples R China.

[Zhang, Chun-hu; Huang, Xi; Ren, Ping; He, Juan; Hu, Sui-yu; Wang, Yang; Qiu, Xin-jian; Xie, Wei-bin; Ji, Hui; Zhang, Ying-jin] Cent S Univ, Xiangya Hosp, Key Unit Tradit Chinese Med Gan SATCM, Changsha 410008, Hunan, Peoples R China.

[Huang, Xi; Liu, Zhao-qian; Zhou, Hong-hao] Cent S Univ, Inst Clin Pharmacol, Lab TCM Pharmacogenet, Changsha 410008, Hunan, Peoples R China.

[Huang, Hui-yong; Xie, Meng-zhou] Hunan Univ Chinese Med, Diag Inst Tradit Chinese Med, Changsha 41007, Hunan, Peoples R China.

通讯机构：

[Huang, Xi] C

Cent S Univ, Xiangya Hosp, Inst Integrated Tradit Chinese & Western Med, Lab Ethnopharmacol, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

Alpha 2-adrenoceptor;Common mechanism;Depression;Gastrointestinal dysfunction;Ghrelin;Meranzin hydrate

期刊：

Neuropharmacology

ISSN：

0028-3908

年：

2013

卷：

页码：

318-325

DOI：

10.1016/j.neuropharm.2012.10.003

基金类别：

Natural Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81072967, 30572339, 81173591]; National Key Clinical Specialist vocational school of TCM encephalopathy; Natural Science Innovation Group Foundation of Hunan Province [12JJ7006]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30801506]

机构署名：

本校为其他机构

院系归属：

中医学院

摘要：

Background: In recent years, the brain gut axis theory has received increasing attention in studies of depression. However, most studies separately address potential antidepressant and prokinetic treatments. Investigations of drugs that could potentially treat comorbid depression and gastrointestinal (GI) dysfunction via a common mechanism of action have not yet been performed in detail. Aim: To find a common mechanism of action of our patented drug, meranzin hydrate (MH), in the antidepressant and prokinetic treatment. Methods: The forced swimming test (FST) model of depression, plasma ghreli...

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Meranzin hydrate exhibits anti-depressive and prokinetic-like effects through regulation of the shared alpha 2-adrenoceptor in the brain–gut axis of rats in the forced swimming test

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