Oleate inhibits hepatic autophagy through p38 mitogen-activated protein kinase (MAPK)

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ning, Jie;Zhao, Chengjiang;Chen, Jian-xiong;Liao, Duan-fang*

通讯作者：

Liao, Duan-fang

作者机构：

[Liao, Duan-fang; Ning, Jie] Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.

[Zhao, Chengjiang; Ning, Jie] Guangdong Med Univ, Affiliated Longhua Cent Hosp, Shenzhen Longhua Dist Cent Hosp, Dept Endocrinol, Shenzhen 518110, Guangdong, Peoples R China.

[Liao, Duan-fang] Hunan Univ Chinese Med, Sch Pharm, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Changsha 410208, Hunan, Peoples R China.

[Chen, Jian-xiong] Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, Sch Med, Jackson, MS 39216 USA.

[Liao, Duan-fang] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Liao, Duan-fang] H

Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

ATF-2;Autophagy;Oleate acid;Ulk1;p38

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2019

卷：

514

期：

页码：

92-97

DOI：

10.1016/j.bbrc.2019.04.073

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81670268, 31371161]; Key Laboratory Funding from Longhua District, Shenzhen [20150827A0410012]; Shenzhen Foundation of Science and Technology [JCYJ20160428141615317]; Fund of Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016A030313026]; The fund of China Hunan Provincial Science & Technology Department [2014FJ6025]

机构署名：

本校为第一且通讯机构

院系归属：

中西医结合学院

药学院

摘要：

Hepatic autophagy plays an important role in lipid metabolism, especially in nonalcoholic fatty liver disease. The relationship between Oleate acid and autophagy is not yet clear. In this work, using mouse epithelial cell hepa1c1c7, we investigated the role of Oleate acid on autophagy and explored its potential mechanisms. The exposure of hepatic cells to Oleate acid resulted in a significant reduction of LC3 accumulation together with enhancement of p62 protein expression and the mRNA levels of ATG7 and BECN1 were reduced as well. Mechanistica...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Oleate inhibits hepatic autophagy through p38 mitogen-activated protein kinase (MAPK)

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问