Human torpor: translating insights from nature into manned deep space expedition

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成果类型：

期刊论文

作者：

Shi, Zhe;Qin, Meng;Huang, Lu;Xu, Tao;Chen, Ying;...

通讯作者：

Wu, RR;Yuan, TF

作者机构：

[Wu, Ren-Rong; Wang, Xiao-Ping; Wu, RR; Shi, Zhe] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha 410011, Hunan, Peoples R China.

[Wu, Ren-Rong; Wang, Xiao-Ping; Wu, RR; Shi, Zhe] Cent South Univ, Xiangya Hosp 2, Dept Psychaitry, Changsha 410011, Hunan, Peoples R China.

[Peng, Zhuang; Liao, Duan-Fang; Liu, Xin-Min; Peng, Sha; Tuo, Qin-Hui; Shi, Zhe] Hunan Univ Chinese Med, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Changsha 410208, Hunan, Peoples R China.

[Chen, Shan-Guang; Li, Ying-Hui; Liu, Xin-Min; Qu, Li-Na; Shi, Zhe] China Astronaut Res & Training Ctr, State Key Lab Space Med Fundamentals & Applicat, Beijing 100094, Peoples R China.

[Yuan, Ti-Fei; Shi, Zhe] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai Key Lab Psychot Disorders, Shanghai 200030, Peoples R China.

通讯机构：

[Yuan, TF ] S

[Wu, RR ] C

Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha 410011, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp 2, Dept Psychaitry, Changsha 410011, Hunan, Peoples R China.

Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai Key Lab Psychot Disorders, Shanghai 200030, Peoples R China.

语种：

英文

关键词：

central nervous system;synthetic torpor;energy metabolism;neurobehavioural functions;manned spaceflight

期刊：

Biological Reviews

ISSN：

1464-7931

年：

2021

卷：

期：

页码：

642-672

DOI：

10.1111/brv.12671

基金类别：

This work was supported by the Space Medical Experiment Project of China Manned Space Program, HYZHXM05003; the opening foundation of the State Key Laboratory of Space Medicine Fundamentals and Application, Chinese Astronaut Research and Training Center, grant NO. SMFA18K02, SMFA18B02, National Natural Science Foundation of China, 31900720; Guangdong Natural Science Foundation, 2019A1515011598; and the Scientific Research Fund of Hunan Provincial Education, 19B422. National Natural Science Foundation of China (81822017), the Science and Technology Commission of Shanghai Municipality (18QA1403700, 18JC1420304), and innovative research team of high-level local universities in Shanghai. Author contributions: all authors wrote the draft together and approved the final version. The authors declare that they have no competing interests.

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摘要：

ABSTRACTDuring a long‐duration manned spaceflight mission, such as flying to Mars and beyond, all crew members will spend a long period in an independent spacecraft with closed‐loop bioregenerative life‐support systems. Saving resources and reducing medical risks, particularly in mental heath, are key technology gaps hampering human expedition into deep space. In the 1960s, several scientists proposed that an induced state of suppressed metabolism in humans, which mimics ‘hibernation’, could be an ideal solution to cope with many issues du...

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Human torpor: translating insights from nature into manned deep space expedition

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