期刊论文

Effects of Silkworm Arisaema Decoction on the Expression of Aquaporim4 in Acute Ischemic Brain Edema in Rats

中文

河南中医

1003-5028

2015

21

12

6-9

10.13862/j.cnki.cn43-1446/r.2015.12.003

湖南省中医药管理局重点资助项目（201329） 湖南省中医药管理局一般资助项目（2013126）

本校为第一机构

目的:探讨僵蚕天南星方对急性缺血性脑水肿大鼠水通道蛋白4（AQP4）表达的影响及其作用机制。方法:将大鼠随机分为3组:假手术组、模型组、僵蚕天南星方组,采用线栓法制备大鼠大脑中动脉缺血再灌注模型,观察缺血220h再灌注2420h、4820h、7220h、9620h204个不同时间点,采用Zausinger评分法观察大鼠神经功能改变,干湿重法测定脑组织含水量,HE染色观察脑组织病理学变化,免疫组织化学法观察大鼠大脑皮层AQP4的表达情况。结果:与模型组比较,僵蚕天南星方组神经功能评分较高（P

Objective： To investigate the effects of Silkworm Arisaema Decoction on the expression of aquaporin 4（AQP4） and its mechanism of action in rats with acute cerebral edema. Method： The SD rats were randomly divided into three groups：the sham operation group, the model group, the Silkworm Arisaema Decoction group. The model of middle cerebral artery occlu- sion was established by thread ligation method. Adult SD rats were observed cerebral ischemia for 2 h, and reperfusion at 24 h, 48 h, 72 h, 96 h respectively. The Zausinger score was used t...