Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke

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成果类型：

期刊论文

作者：

Linquan Liu;Yahong Cai;Changqing Deng*

通讯作者：

Changqing Deng

作者机构：

[Yahong Cai] Chronic Disease Management Department, The First Hospital of Hunan University of Chinese Medicine, Changsha, China

[Changqing Deng] The Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, China

[Linquan Liu] Chronic Disease Management Department, The First Hospital of Hunan University of Chinese Medicine, Changsha, China<&wdkj&>The Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, China

通讯机构：

[Changqing Deng] T

The Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, China

语种：

英文

关键词：

Ischemic stroke (IS);Pyroptosis;Random forest learning;Annexin A3 (ANXA3);ADM

期刊：

European Journal of Medical Research

ISSN：

2047-783X

年：

2023

卷：

期：

页码：

1-15

DOI：

10.1186/s40001-023-01564-y

基金类别：

This study was supported by Open Fund for Integrated Traditional Chinese and Western Medicine (2020ZXYJH33), Key project of Hunan Education Department (19A381), Hunan graduate Research Innovation Project (CX20220785), Natural Science Foundation of Hunan Province (2020JJ4474) and 2023 Scientific Research Plan Topics of Hunan Provincial Health Commission (D202314018599).

机构署名：

本校为第一且通讯机构

院系归属：

中西医结合学院

摘要：

Pyroptosis plays an important role in the pathological process of ischemic stroke (IS). However, the exact mechanism of pyroptosis remains unclear. This paper aims to reveal the key molecular markers associated with pyroptosis in IS. We used random forest learning, gene set variation analysis, and Pearson correlation analysis to screen for biomarkers associated with pyroptosis in IS. Middle cerebral artery occlusion/reperfusion (MCAO/R) and oxygen and glucose deprivation/reoxygenation (OGD/R) models were constructed in vitro and in vivo. Cells ...

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Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke

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