Tumor-infiltrating lymphocytes are associated with β -catenin overexpression in breast cancer

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成果类型：

期刊论文

作者：

Ma, Xingcong;Zhao, Xiaoyao;Yan, Wanjun;Yang, Jun;Zhao, Xixi;...

通讯作者：

Zhang, Shuqun

作者机构：

[Yan, Wanjun; Zhang, Shuqun; Zhao, Xixi; Zhao, Xiaoyao; Zhang, Hong; Ma, Xingcong] Xi An Jiao Tong Univ, Dept Oncol, Affiliated Hosp 2, 157 West 5th Rd, Xian 710004, Shaanxi, Peoples R China.

[Yang, Jun] Xi An Jiao Tong Univ, Dept Pathol, Affiliated Hosp 2, Xian 710004, Shaanxi, Peoples R China.

[Hui, Yuxin] Hunan Univ Chinese Med, Sch Tradit Chinese Med, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Zhang, Shuqun] X

Xi An Jiao Tong Univ, Dept Oncol, Affiliated Hosp 2, 157 West 5th Rd, Xian 710004, Shaanxi, Peoples R China.

语种：

英文

关键词：

CD8+ TILs;FOXP3+ TILs;Tumor infiltrating lymphocytes;Wnt/beta-catenin signaling;breast cancer

期刊：

Cancer Biomarkers

ISSN：

1574-0153

年：

2018

卷：

期：

页码：

639-650

DOI：

10.3233/CBM-170708

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81274136]

机构署名：

本校为其他机构

摘要：

BACKGROUND: Inhibition of lymphocytes infiltration and activity may impair antitumor immune response and limit treatment responsiveness. Wnt/β-catenin pathway has been suggested to contribute to immune evasion in tumor by suppressing the function of immune cells and excluding T cell infiltration. However, the effects of Wnt/β-catenin on TILs recruitment remain controversial. OBJECTIVE: We aimed to investigate whether intratumoral Wnt/β-catenin signaling could affect the lymphocyte infiltration in breast cancer. METHODS: The distribution of s...

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Tumor-infiltrating lymphocytes are associated with β -catenin overexpression in breast cancer

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