期刊论文

Relationship between ApolipoproteinA5 c.553G

中文

中西医结合心脑血管病杂志

1672-1349

2012

10

5

542-544

10.3969/j.issn.1672-1349.2012.05.017

湖南省教育厅科研基金资助项目（No.09C726）； 湖南中医药大学中医诊断学（国家重点学科）,中医基础（校级重点学科）资助；

本校为第一机构

目的 探讨载脂蛋白A5(APOA5)c.553G>T基因多态性与冠心病痰证的关系.方法 运用聚合酶链反应-限制性片段长度多态性分析技术(PCR-RFLP)对湖南地区58例冠心病痰证、51例冠心病非痰证、73例非冠心病痰证患者及74名健康人的APOA5c.553G>T基因型进行检测,同时检测所有研究对象的血脂、血压及体质量指数.结果 256例受检者中,APOA5 c.553G>T位点GG型221例(86.33%),GT型35例(13.67%),TT型0;G等位基因频率93.16%,T等位基因频率6.84%.c.553GT型血清TG水平明显高于GG型.病例-对照研究提示c.553T等位基因是冠心病痰证发生的危险因素,但多因素Logistic回归分析不支持c.553T是上述病证发生的独立危险因素.结论...

Objective To explore the relationship between the polymorphisms of apolipoproteinA5(APOA5) gene(c.553G>T) and phlegm stagnation syndrome(PSS) in patients with coronary heart disease(CHD).Methods Patients suffering from the PSS of CHD(n=58),Patients suffering from the no-PSS of CHD(n=51),Patients suffering from the PSS without CHD(n=73) and healthy controls(n=74) were grouped and compared in this study.Using polymerase chain reaction-restriction fragment length polymorphisms(PCR-RFLP) technique to analyze the APOA5(c.553G>T) genotypes.Serum lipids,blood pressure and body mass index in the patie...