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Role of MicroRNA, LncRNA, and Exosomes in the Progression of Osteoarthritis: A Review of Recent Literature

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成果类型:
期刊论文
作者:
Xie, Fang;Liu, Yong-li;Chen, Xiu-yuan;Li, Qian;Zhong, Jia;...
通讯作者:
Shao, XF;Wu, GB
作者机构:
[Li, Qian; Shao, Xian-fang; Dai, Bin-yu; Zhong, Jia; Liu, Yong-li; Chen, Xiu-yuan; Xie, Fang] Hunan Univ Tradit Chinese Med, Affiliated Changde Hosp, 588 Binhu Rd, Changde 415000, Peoples R China.
[Wu, Guan-bao] Hunan Acad Tradit Chinese Med, Affiliated Hosp, Dept Orthopaed, 58 Lushan Rd, Changsha 410006, Peoples R China.
通讯机构:
[Wu, GB ; Shao, XF ] H
Hunan Univ Tradit Chinese Med, Affiliated Changde Hosp, 588 Binhu Rd, Changde 415000, Peoples R China.
Hunan Acad Tradit Chinese Med, Affiliated Hosp, Dept Orthopaed, 58 Lushan Rd, Changsha 410006, Peoples R China.
语种:
英文
关键词:
long untranslated RNA;microRNA;long untranslated RNA;microRNA;3' untranslated region;apoptosis;cell proliferation;chondrocyte;disease association;exosome;extracellular matrix;gene expression level;gene expression regulation;gene targeting;human;inflammation;intracellular transport;osteoarthritis;pathogenesis;Review;RNA binding;target cell;disease exacerbation;exosome;metabolism;osteoarthritis;pathology;Disease Progression;Exosomes;Humans;MicroRNAs;Osteoarthritis;RNA, Long Noncoding
期刊:
Orthopaedic Surgery
ISSN:
1757-7853
年:
2020
卷:
12
期:
3
页码:
708-716
基金类别:
The research was funded by the National Natural Science Foundation of China (Grant Number: 81874476), Hunan Administration of Traditional Chinese Medicine (Grant Number: 201902), and Changde Science and Technology Bureau (Grant Number: 2012SK06).
机构署名:
本校为第一且通讯机构
摘要:
Osteoarthritis (OA) is a common clinical degenerative disease characterized by the destruction of articular cartilage, which has an increasing impact on people's lives and social economy. The pathogenesis of OA is complex and unclear, and there is no effective way to block its progress. The study of the pathogenesis of OA is the prerequisite for the early diagnosis and effective treatment of OA. To define the pathogenesis of OA, this review considers the pathological mechanism of OA that involves microRNA, lncRNA, and exosomes. More and more ev...

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