miR-203 promotes HaCaT cell overproliferation through targeting LXR-α and PPAR-γ

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xiao, Yueyuan;Wang, Haizhen;Wang, Chang;Zeng, Bijun;Tang, Xueyong;...

通讯作者：

Yang, Zhibo

作者机构：

[Huang, Pan; Wang, Chang; Zeng, Bijun; Peng, Youhua; Xiao, Yueyuan; Tang, Xueyong; Wang, Haizhen; Zhang, Yujin; Yang, Zhibo; Luo, Meijunzi] Hunan Univ Chinese Med, Domest Class Discipline Construct Project Chinese, Affiliated Hosp 2, Dept Dermatol, Changsha 410005, Hunan, Peoples R China.

[Xiao, Yueyuan] Fourth Mil Med Univ, Xijing Hosp, Dept Dermatol, Xian 710032, Peoples R China.

通讯机构：

[Yang, Zhibo] H

Hunan Univ Chinese Med, Domest Class Discipline Construct Project Chinese, Affiliated Hosp 2, Dept Dermatol, Changsha 410005, Hunan, Peoples R China.

语种：

英文

关键词：

Psoriasis;keratinocyte hyperproliferation;miR-203;LXR-alpha;PPAR-gamma

期刊：

Cell Cycle

ISSN：

1538-4101

年：

2020

卷：

期：

页码：

1928-1940

DOI：

10.1080/15384101.2020.1783934

基金类别：

National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [81573985]

机构署名：

本校为第一且通讯机构

院系归属：

第二中医临床医学院

摘要：

Psoriasis is an immune-mediated chronic inflammatory skin disease. Keratinocyte hyperproliferation has been regarded as a significant event in psoriasis pathogenesis. Considering the vital role of miRNA-mediated mRNA repression in psoriasis pathogenesis, in the present study, we attempted to investigate the mechanism of keratinocyte overproliferation from the point of miRNA-mRNA regulation. Both online microarray expression profiles and experimental results indicated that the expression of LXR-α and PPAR-γ was downregulated in psoriasis lesio...

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miR-203 promotes HaCaT cell overproliferation through targeting LXR-α and PPAR-γ

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