Network Pharmacology and Experimental Analyses on Astragalus membranaceus (Huangqi) Effects on Endotoxin-induced Uveitis Model in Rats

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Lu, Jing;Wu, Yujie;Yang, Yijing;Zhou, Jing;Huang, Bo;...

通讯作者：

Peng, QH

作者机构：

[Lu, Jing; Zhang, Xiaohuan; Wu, Yujie; Xie, Chengfeng] Hunan Univ Chinese Med, Med Sch, Changsha, Hunan, Peoples R China.

[Huang, Bo; Yang, Yijing] Hunan Univ Chinese Med, Chinese Med Sch, Changsha, Hunan, Peoples R China.

[Lu, Jing] Hunan Prov Engn Technol Res Ctr Prevent & Treatmen, Changsha, Hunan, Peoples R China.

[Peng, Qinghua; Yang, Yijing] Hunan Prov Key Lab Prevent & Treatment Ophthalmol, Changsha, Hunan, Peoples R China.

[Peng, Qinghua] Hunan Prov Engn Res Ctr Prevent & Treatment Ophtha, Changsha, Hunan, Peoples R China.

通讯机构：

[Peng, QH ] H

Hunan Prov Key Lab Prevent & Treatment Ophthalmol, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Endotoxin-induced uveitis;traditional Chinese medicine;network pharmacology;Astragalus membranaceus;total flavonoids of Astragalus

期刊：

Pharmacognosy Magazine

ISSN：

0973-1296

年：

2023

DOI：

10.1177/09731296231169576

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

Objectives This study is aimed at identifying critical therapeutic targets of Astragalus membranaceus (Huangqi (HQ)) and investigating the effects and mechanisms of HQ treating uveitis. The potential drug targets of HQ and main active ingredients were obtained from the traditional Chinese medicine (TCM) systems pharmacology database and analysis platform (TCMSP, http://tcmspnw.com). Materials and Methods Cytoscape software was used to identify the disease targets of uveitis. Drug targets and disease targets were compared, and intersected hubs were applied for the active ingredient-target netwo...

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Network Pharmacology and Experimental Analyses on Astragalus membranaceus (Huangqi) Effects on Endotoxin-induced Uveitis Model in Rats

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