Research progress on adenosine in central nervous system diseases

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成果类型：

期刊论文

作者：

Liu, Ying-Jiao;Chen, Jiao;Li, Xun;Zhou, Xin;Hu, Yao-Mei;...

通讯作者：

Chen, NH

作者机构：

[Li, Xun; Liu, Ying-Jiao; Hu, Yao-Mei; Peng, Ye; Chen, Nai-Hong] Hunan Univ Chinese Med, Coll Pharm, Changsha, Hunan, Peoples R China.

[Liu, Ying-Jiao; Chen, Nai-Hong; Chen, Jiao; Zhou, Xin; Chu, Shi-Feng] Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing, Peoples R China.

[Liu, Ying-Jiao; Chen, Nai-Hong; Chen, Jiao; Zhou, Xin; Chu, Shi-Feng] Chinese Acad Med Sci, Neurosci Ctr, Beijing, Peoples R China.

[Liu, Ying-Jiao; Chen, Nai-Hong; Chen, Jiao; Zhou, Xin; Chen, NH; Chu, Shi-Feng] Peking Union Med Coll, 1 Xiannongtan St, Beijing 100050, Peoples R China.

[Li, Xun; Liu, Ying-Jiao; Hu, Yao-Mei; Peng, Ye; Chen, Nai-Hong] Hunan Engn Technol Ctr Standardizat & Funct Chine, Changsha, Hunan, Peoples R China.

通讯机构：

[Chen, NH ] P

Peking Union Med Coll, 1 Xiannongtan St, Beijing 100050, Peoples R China.

Chinese Acad Med Sci, Dept Pharmacol, Inst Mat Med, 1 Xiannongtan St, Beijing 100050, Peoples R China.

语种：

英文

关键词：

adenosine;Alzheimer's disease;cerebral ischemia;depression;epilepsy;Parkinson's disease;sleep disorders;structural modification

期刊：

CNS Neuroscience & Therapeutics

ISSN：

1755-5930

年：

2019

卷：

期：

页码：

899-910

DOI：

10.1111/cns.13190

基金类别：

Funding information Project of NDRC and State Administration of Traditional Chinese Medicine. Grant/Award Number: ZYBZH-Y-HUN-24 and ZYBZH-Y-HEB-16. This work was supported by grants from the Project of NDRC and State Administration of Traditional Chinese Medicine (No. ZYBZH-Y-HUN-24 and ZYBZH-Y-HEB-16) for fund support.

机构署名：

本校为第一机构

院系归属：

药学院

摘要：

As an endogenous neuroprotectant agent, adenosine is extensively distributed and is particularly abundant in the central nervous system (CNS). Under physiological conditions, the concentration of adenosine is low intra- and extracellularly, but increases significantly in response to stress. The majority of adenosine functions are receptor-mediated, and primarily include the A1, A2A, A2B, and A3 receptors (A1R, A2AR, A2BR, and A3R). Adenosine is currently widely used in the treatment of diseases of the CNS and the cardiovascular systems, and the mechanisms are related to the disease types, dise...

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Research progress on adenosine in central nervous system diseases

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