期刊论文

中文

针刺研究

1000-0607

2015

40

2

94-98

10.13702/j.1000-0607.2015.02.002

No.81273861:国家自然科学基金 No.81473754:国家自然科学基金 No.2012FJ4361:湖南省科技厅科技项目

本校为第一机构

目的:探讨电针手厥阴心包经穴对急性脑缺血大鼠神经修复的作用机制.方法:将SD大鼠随机分为正常组、假手术组、模型组、心包经组、肺经组,每组10只.采用颈外动脉插入线栓法复制局灶性脑缺血模型.心包经组取“天泉”“曲泽”“内关”“大陵”穴,肺经组取“天府”“尺泽”“列缺”“太渊”穴,于造模后6、24、48、72 h进行电针治疗,每次30 min.用酶联免疫吸附法检测血清神经生长因子(NGF)和神经生长抑制因子(Nogo-A)含量,免疫组化法检测脑梗死区NGF和Nogo-A的表达.结果:与正常组、假手术组比较,模型组能上调NGF在血清中的含量及脑梗死区的表达(P＜0.01),心包经组、肺经组较模型组进一步上调(P＜0.01...

OBJECTIVE: To observe the effect of Electroacupuncture (EA) stimulation of "Tianquan"(PC 2), "Quze" (PC 3), "Neiguan" (PC 6), "Daling" (PC 7) of the Pericardium Meridian on cerebral angiogenesis in cerebral ischemia (CI) rats, so as to reveal its mechanisms underlying improvement of stroke. METHODS: A total of 50 SD rats were equally randomized into normal control, sham, model, EA-Pericardium-Meridian acupoints (EA-PCM) and EA-Lung-Meridian acupoint (EA-LUM) groups. The CI model was established by occlusion of the middle cerebral artery. EA (2-4 V, 20 Hz) was applied to PC 2, PC 3, PC 6, PC 7 ...