期刊论文

Effect of Point-moxibustion and Electroacupuncture on the Expression of Endothelial Nitric Oxide Synthase mRNA and Angiotensin 2 mRNA in Gastric Antrum in Diabetic Gastroparesis Rats

中文

针刺研究

1000-0607

2017

42

3

240-245

10.13702/j.1000-0607.2017.03.009

No.2014CB543102:国家重点基础研究发展计划（973计划） No.14B129:湖南省教育厅科学研究项目 No.81673886:国家自然科学基金 81403487:国家自然科学基金 No.2016CX26:校创新性课题

本校为第一机构

目的:观察点灸、电针对糖尿病胃轻瘫(DGP)大鼠胃肠运动和内皮细胞型一氧化氮合酶(eNOS)、血管紧张素Ⅱ(AT Ⅱ)mRNA表达的影响,探讨点灸、电针治疗DGP的效应差异及作用机制。方法:SD大鼠随机分为空白组、模型组、点灸组、电针组,每组10只。采用腹腔注射2%链脲佐菌素配合高脂高糖饮食建立DGP大鼠模型。点灸组和电针组选取“足三里”“三阴交”“梁门”穴,点灸组于0、10、20 min对穴位进行点灸,电针组电针20 min,每日治疗1次,治疗15 d。检测各组大鼠血糖、胃排空率和小肠推进率,ELISA法检测血浆内皮素1(ET-1)含量,Real-time PCR法检测胃窦部组织eNOS mRNA、AT Ⅱ mRNA的表达。结果:与空白组比较,模...

Objective: To observe the effect of point-moxibustion and electroacupuncture(EA) on gastrointestinal motility, and expression of endothelial nitric oxide synthase(eNOS) mRNA and angiotensin 2(AT Ⅱ) mRNA in gastric antrum in diabetic gastroparesis(DGP) rats, so as to reveal the different effect between point-moxibustion and EA, and explore the mechanism underlying improvement of DGP. Methods: Forty SD rats were randomly divided into normal, model, point-moxibustion and EA groups, 10 rats in each group. The DGP model was established by intraperi...