期刊论文

Effect of Catgut Implantation on Spatial Learning-memory Ability, Expression of Hippocampal Protein Kinase C Interacting Protein 1 and GluR 2 and Ca~(2+) Content in Rats with Chronic Ischemic Cognitive Impairment

中文

针刺研究

1000-0607

2018

43

6

347-352

10.13702/j.1000-0607.170385

湖南省教育厅优秀青年基金项目（No.16B197） 湖南省研究生创新项目（No.CX2017B453） 湖南省“十二五”重点学科针灸推拿学开放基金重点资助项目（No.2015-02）

本校为第一机构

目的:观察穴位埋线对慢性缺血性认知障碍大鼠空间学习记忆能力及海马蛋白激酶C相互作用蛋白1(PICK 1)、谷氨酸受体2(GluR 2)及Ca~(2+)水平的影响,探讨穴位埋线改善缺血性认知障碍的可能途径。方法:雄性SD大鼠随机分为假手术组、模型组、埋线组、药物组,每组14只。采用双侧颈总动脉永久性结扎法复制慢性缺血性认知障碍模型。埋线组取“百会”“大椎”、双侧“肾俞”“悬钟”穴埋线,每周1次,共埋线4次;药物组予以单唾液酸四己糖神经节苷脂钠注射液腹腔注射(0.33 mg/kg),每天1次,共4周。采用Morris水迷宫进行学习记忆能力测试,尼氏染色法观察大鼠海马组织内尼氏小体病理变化,蛋白免疫印迹法检测大鼠...

OBJECTIVE: To observe the effect of catgut embedment at "Baihui" (GV 20), "Dazhui" (GV 14), etc. on learning-memory ability, expression of hippocampal protein kinase C interacting protein 1 (PICK 1) and glutamate receptor 2 (GluR 2) proteins and level of calcium ions, so as to explore its mechanism underlying improvement of vascular cognitive impairment. METHODS: A total of 56 male SD rats were randomly divided into sham operation, model, catgut embedment and medication groups (n=14 in each). The chronic ischemic cognitive impairment model was established by permanent occlusion of bilate-ral c...