期刊论文

Effect of Herbal-cake-separated Moxibustion on Blood Lipid Levels and Expression of Hepatic PPARγand SR-B 1Proteins and Genes in Hyperlipidemia Atherosclerosis Rabbits

中文

针刺研究

1000-0607

2018

43

2

86-91

10.13702/j.1000-0607.170729

No.81373716:国家自然科学基金 81704182:国家自然科学基金 :国家中医药局推广项目 No.15C1061:教育厅项目

本校为第一机构

目的:观察隔药饼灸对高脂血症合并动脉粥样硬化(AS)兔胆固醇逆转运中过氧化酶体增殖物激活型受体γ(PPARγ)、B类Ⅰ型清道夫受体(SR-B 1)蛋白及基因表达的影响,探讨隔药饼灸促胆固醇逆转运抗AS形成的作用机制。方法:新西兰大耳白兔随机分为正常组、模型组、隔药饼灸组、辛伐他汀组,每组10只。采用高胆固醇饲料配合丙基硫氧嘧啶喂养方式制备高脂血症合并AS兔模型。隔药饼灸组予隔药饼灸处理,施灸穴位分为两组,第1组为“巨阙”与双侧“天枢”“丰隆”,第2组为双侧“心俞”“肝俞”“脾俞”,两组穴位交替使用;辛伐他汀组将辛伐他汀粉(1.96 mg·kg~(-1)·d~(-1))拌入第1口饲料;均每天治疗1次,连续4周...

OBJECTIVE: To observe the effect of herbal-cake-separated moxibustion on blood lipid levels and expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and scavenger receptor B 1 (SR-B 1) proteins and genes in liver of hyperlipidemia atherosclerosis rabbits, so as to explore its mechanism underlying anti-atherosclerosis formation. METHODS: Forty male New Zealand white rabbits were randomly divided into normal control, model, moxibustion and Simvastatin groups (n10 rabbits in each group). The hyperlipidemia atherosclerosis model was established by high cholesterol diet and pr...