期刊论文

中文

针刺研究

1000-0607

2018

43

3

152-162

10.13702/j.1000-0607.170436

国家自然科学基金面上项目（No.81574080） 湖南省中医药管理局课题（No.201521） 湖南省高校创新平台开放基金项目（No.15k093）

本校为第一机构

目的:基于核磁共振氢谱(~1H NMR)研究电针"内关"穴对心肌缺血再灌注损伤(MIRI)大鼠血清和心肌组织代谢物的影响,探讨电针"内关"穴对MIRI大鼠代谢模式的影响。方法:30只SD雄性大鼠随机分为对照组、模型组、电针组。对照组:不予电针,仅用鼠板束缚大鼠,每次20 min,每日1次,持续7 d;模型组予心肌缺血再灌注造模:至第7天后结扎冠状动脉左前降支40 min后恢复血流60 min;电针组(频率10 Hz/50 Hz,脉冲宽度0.5 ms,强度1 mA):每日电针双侧"内关"穴1次,时间20 min,持续7 d,于第7天电针后造模。造模结束后,收集3组大鼠的血清和心肌组织。利用~1H NMR进行代谢物检测并利用多元统计方法主成分分析(PCA)、正交偏...

Objective We have repeatedly demonstrated that electroacupuncture (EA) of "Neiguan"(PC 6) can im-prove myocardial ischemia in rats .The present study was designed to investigate the metabolomic profile of peripheral blood se-rum and myocardium involving EA-induced improvement of myocardial ischemia-reperfusion injury (MIRI) in rats by using nuclear magnetic resonance spectroscopy .Methods Thirty male SD rats were equally randomized into blank control ,model and EA groups .Rats of the control group were only banded for 20 min ,once a day for 7 days .The MIRI model was established by occlu-sion ...