期刊论文

Effect of acupoint catgut embedding on intestinal mucosal epithelial barrier in ulcerative colitis rats

中文

针刺研究

1000-0607

2021

46

03

201-208

10.13702/j.1000-0607.200388

国家自然科学基金项目（No.81874466）； 湖南省中医药管理局重点课题（No.201903）；

本校为第一机构

目的:观察穴位埋线对\"虚、瘀\"状态下溃疡性结肠炎(UC)模型大鼠肠黏膜上皮屏障的影响,探讨其改善UC的作用机制。方法:雄性SD大鼠随机分为正常组12只与造模组48只。造模组采用腺嘌呤、番泻叶分阶段灌胃制造大鼠\"虚、瘀\"状态,接着用5%2,4,6-三硝基苯磺酸(TNBS,100 mg/kg)加0.25 mL 50%乙醇灌肠建立UC大鼠模型。将造模成功的大鼠随机分为模型组、柳氮磺吡啶组和穴位埋线组,每组10只。穴位埋线组予以双侧\"天枢\"\"足三里\"\"膈俞\"\"脾俞\"\"肾俞\"\"大肠俞\"埋线治疗,14 d埋线1次,共3次。柳氮磺吡啶组予以柳氮磺吡啶灌胃,每日1次,共42 d。观察大鼠一般状态及体质量变化,采用肉眼及HE染色观察大...

Objective To observe the effect of acupoint catgut embedding on intestinal mucosal epithelial injury,and expression of epithelial tight junction proteins and mRNAs and protein kinase C(PKC)protein(intestinal mucosal epithelial barrierrelated molecules)in rats with experimental ulcerative colitis(UC)of“deficiency-stasis”type,so as to explore its mechanisms underlying improvement of UC.Methods Male SD rats were randomly divided into normal control,UC model,medication(sulfasalazine, SASP)and catgut-embedding groups.The“deficiency-stasis”type U...