期刊论文

中文

针刺研究

1000-0607

2022

47

3

216-223

10.13702/j.1000-0607.20210766

湖南省自然科学基金项目（No.2018JJ3384）； 湖南省中医药科研计划项目（No.2021233）；

本校为第一机构

目的：观察电针对血管性痴呆大鼠肠道菌群及血清白细胞介素（IL）-1β、IL-18的影响。方法：采用改良双侧颈总动脉永久结扎法制备血管性痴呆大鼠模型，将造模成功后的大鼠随机分为模型组、基础电针组、脑肠共治电针组、针药结合组，每组10只，另设假手术组10只。基础电针组给予“百会”“大椎”“肾俞”电针30 min；脑肠共治电针组采用基础电针组穴结合“足三里”电针30 min；针药结合组采用基础电针组穴结合益生菌灌胃联合治疗，各组干预均每日1次，连续4周。采用水迷宫实验评价各组大鼠治疗前后学习记忆能力，ELISA法测定血清IL-1β、IL-18含量，HE染色法观察肠黏膜形态学改变，透视电镜观察大...

OBJECTIVE: To observe the effect of electroacupuncture (EA) of "Baihui"(GV20), "Dazhui"(GV14), "Shenshu" (BL23)and "Zusanli"(ST36) on the intestinal flora and serum interleukin (IL)-1β and IL-18 contents in vascular dementia (VD) rats. METHODS: SD rats were randomized into sham operation, VD model, GV20+GV14+BL23 (EA-basic acupoints), and EA-basic acupoints+ST36 and EA-basic acupoints+probiotics groups (n=10 in each group). EA (10 Hz/50 Hz) was conducted for 30 min, once daily for 4 consecutive weeks. Rats of the EA-basic acupoints+probiotics ...