期刊论文

中文

针刺研究

1000-0607

2022

47

8

696-702

10.13702/j.1000-0607.20210695

国家自然科学基金青年基金项目（No.81804204）;国家自然科学基金面上项目（No.82074565）； 湖南省自然科学基金项目（No.2020JJ5433）；

本校为第一机构

目的:观察电针"足三里""关元"对佐剂性关节炎(AIA)大鼠滑膜组织细胞凋亡率及其他凋亡蛋白含量的影响,探讨电针通过死亡受体(Fas)凋亡途径调节滑膜细胞凋亡和抗炎治疗类风湿关节炎(RA)的机制.方法:SD大鼠按照随机数字表法分为正常组、模型组、甲氨蝶呤组、电针组,每组6只.选用弗氏完全佐剂注射法制备AIA大鼠模型.造模后第3天开始干预,甲氨蝶呤组按照0.35 mg/kg的剂量进行灌胃,每周2次;电针组予以电针"足三里""关元",每次20 min,每周6次;两组均干预4周.用足趾容积测量仪测量各组大鼠左后肢足趾容积,HE染色观察踝关节滑膜组织形态变化,ELISA法检测大鼠血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1(I...

OBJECTIVE: To observe the effect of electroacupuncture (EA) of "Zusanli"(ST36) and "Guanyuan"(CV4) on the apoptosis rate of synoviocytes and protein expression of Fas, FasL and Caspase-3 in synovial tissue of adjuvant-induced arthritis (AIA) rats, so as to explore its mechanisms underlying improvement of rheumatoid arthritis （RA）. METHODS: A total of 24 rats were randomly divided into normal, model, medication and EA groups, with 6 rats in each group. The AIA model was established by injection of complete Freund's adjuvant (CFA, 0.1 mL) into ...