期刊论文

中文

针刺研究

1000-0607

2022

47

4

314-320

10.13702/j.1000-0607.20210361

国家自然科学基金面上项目（No.81603705）； 湖南省“国内一流培育学科”中西医结合开放基金项目（No.2020ZXYJH37）； 湖南省教育厅资助科研项目（No.18C0367）；

本校为第一机构

目的：观察电针“上巨虚”“天枢”对2-4-6三硝基苯磺酸（TNBS）/乙醇诱导的溃疡性结肠炎（UC）大鼠核转录因子-κB（NF-κB）/NOD样受体热蛋白结构域3（NLRP3）炎性小体信号通路相关蛋白表达的影响，探讨电针治疗UC的部分作用机制。方法：SD大鼠随机分成空白组、模型组、美沙拉嗪组和电针组，每组12只。采用TNBS/乙醇灌肠法制备UC大鼠模型。电针组予电针双侧“上巨虚”“天枢”穴，每日1次，每次20 min，共10次；美沙拉嗪组予美沙拉嗪混悬液（0.2 g/kg）灌胃，每日1次，共10次。观察大鼠一般情况，计算大鼠疾病活动指数（DAI）；肉眼结合HE染色观察结肠黏膜损伤情况及结肠组织形态学变化，并评...

Objective To observe the effect of electroacupuncture(EA) of “Shangjuxu”(ST37) and “Tianshu”(ST25) on colonic mucosal injury and activities of nuclear factor-κB(NF-κB)/Nod-like receptor family, pyrin domain-containing 3(NLRP3) inflammasome signaling in the colonic tissue in rats with ulcerative colitis(UC), so as to explore its mechanisms underlying improvement of UC. Methods Male SD rats were randomly divided into blank, model, medication and EA groups, with 12 rats in each group. The UC model was established by enema of 2-4-6 trinitrobe...