期刊论文

M echanisms of acupuncture for primary dysmenorrhea based on PI3K/Akt/mTOR signaling pathway in rats

中文

针刺研究

1000-0607

2023

48

12

1258-1265

10.13702/j.1000-0607.20230007

No.82004490:国家自然科学基金 No.2021JJ40402:湖南省自然科学基金青年项目 No.20K091:湖南省教育厅创新平台开放基金项目

本校为第一机构

目的:观察电针对原发性痛经(PDM)大鼠子宫组织磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路的影响,探讨电针治疗PDM的作用机制。方法:雌性SD大鼠随机分为空白组、模型...展开更多 目的:观察电针对原发性痛经(PDM)大鼠子宫组织磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路的影响,探讨电针治疗PDM的作用机制。方法:雌性SD大鼠随机分为空白组、模型组和电针组,每组10只。采用苯甲酸雌二醇皮下注射联合缩宫素腹腔注射法复制PDM大鼠模型。电针组予“关元”和双侧“三阴交”电针20 min,1次/d,连续10 d。观察并比较各组大鼠扭体次数、...

ObjectiveTo observe the effect of electroacupuncture(EA)on phosphatidylinositol-3-kinases(PI3K)/protein kinase B(Akt)/m am m alian target of rapam ycin(m TOR)signaling pathway of uterus tissue in rats with pri⁃m ary dysm enorrhea(PDM),so as to investigate its m echanism...MORE ObjectiveTo observe the effect of electroacupuncture(EA)on phosphatidylinositol-3-kinases(PI3K)/protein kinase B(Akt)/m am m alian target of rapam ycin(m TOR)signaling pathway of uterus tissue in rats with pri⁃m ary dysm enorrhea(PDM),so as to investigate its m echanism...